Date published: 2026-4-5

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1,3-Propanesultone (CAS 1120-71-4)

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Alternate Names:
1,3-Propanesulfonate; 3-Hydroxypropanesulfonic acid γ-sultone
CAS Number:
1120-71-4
Molecular Weight:
122.14
Molecular Formula:
C3H6O3S
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,3-Propanesultone is a cyclic sulfonic ester that is used as a reagent in biochemistry. It is a small, three-membered ring compound that contains a sulfur atom and three oxygen atoms. 1,3-Propanesultone′s ability to modify proteins and peptides, particularly by reacting with thiol groups on cysteine residues. The reaction of 1,3-propanesultone with thiol groups forms stable sulfonate linkages, which can be useful for various biochemical applications. Due to its reactivity with thiol-containing biomolecules, 1,3-propanesultone is used in the modification of enzymes, antibodies, and other proteins. Its small size and high reactivity make it a useful for studying the structure and function of thiol-containing biomolecules in biochemistry.


1,3-Propanesultone (CAS 1120-71-4) References

  1. Zwitterion-functionalized polymer microspheres as a sorbent for solid phase extraction of trace levels of V(V), Cr(III), As(III), Sn(IV), Sb(III) and Hg(II) prior to their determination by ICP-MS.  |  Jia, X., et al. 2018. Mikrochim Acta. 185: 228. PMID: 29594828
  2. Enhanced photodynamic antimicrobial activity of surface modified SiNPs doped with zinc(II) phthalocyanines: The effect of antimicrobial ampicillin and extra charges from a sultone.  |  Magadla, A. and Nyokong, T. 2020. Photodiagnosis Photodyn Ther. 32: 101996. PMID: 32911079
  3. Alkylation of Adenine, Adenosine, and NAD+ with 1,3-Propanesultone. Synthesis of N6-(3-sulfonatopropyl)-NAD+, a new NAD+ derivative with substantial coenzyme activity  |  Gianconno Carrea, Gianluca Ottolina, Sergio Riva, Bruno Danieli, Giordano Lesma, Giovanni Palmisano. 1988. 71: 762-772.
  4. Synthesis and proton conductivity of sulfopropylated poly(benzimidazole) films  |  Mitsuyasu Kawahara, Masahiro Rikukawa, Kohei Sanui, Naoya Ogata. 2000. Solid State Ionics. 136-137: 1193-1196.
  5. Synthesis and thermal degradation of poly(n-butylisocyanate) modified by 1,3-propanesultone  |  Alina Dereszewska, Roberto Olayo, Judith Cardoso. 2003. 90: 3594-3601.
  6. 1,3-Propanesultone as an effective functional additive to enhance the electrochemical performance of over-lithiated layered oxides  |  Taeeun Yima, Su Hyun Kima, Sang-Gil Wooa, Kyungjun Leea, Jun Ho Songa, Woosuk Choa, Ki Jae Kima, Jeom-Soo Kim*ab and Young-Jun Kima. 2014. RSC Adv. 4: 19172-19176.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,3-Propanesultone, 10 g

sc-213515
10 g
$60.00

1,3-Propanesultone, 50 g

sc-213515A
50 g
$126.00

1,3-Propanesultone, 500 g

sc-213515B
500 g
$180.00

1,3-Propanesultone, 1 kg

sc-213515C
1 kg
$360.00

1,3-Propanesultone, 2.5 kg

sc-213515D
2.5 kg
$860.00

1,3-Propanesultone, 5 kg

sc-213515E
5 kg
$1668.00