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1,3-Dipropyl-8-phenylxanthine (CAS 85872-53-3)

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Application:
1,3-Dipropyl-8-phenylxanthine is a selective Adenosine A1-R antagonist
CAS Number:
85872-53-3
Purity:
>98%
Molecular Weight:
312.37
Molecular Formula:
C17H20N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.

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1,3-Dipropyl-8-phenylxanthine is a research compound used primarily to study adenosine receptors. Its role as an adenosine receptor antagonist allows for the investigation of signal transduction pathways mediated by these receptors, which are critical to cardiovascular, neurological, and renal functions. By inhibiting adenosine receptors, 1,3-Dipropyl-8-phenylxanthine aids in dissecting their involvement in processes such as cardiac rhythm regulation, neurotransmitter release, and the modulation of inflammatory responses. The compound is also applied in the study of vasodilation mechanisms and the characterization of receptor subtypes, providing insights into the design of selective receptor modulators. In addition, 1,3-Dipropyl-8-phenylxanthine is used in assays to determine the affinity and selectivity of other compounds for adenosine receptors, supporting the development of new research tools and potential modulators.


1,3-Dipropyl-8-phenylxanthine (CAS 85872-53-3) References

  1. Role of adenosine A(1) receptor in the perifornical-lateral hypothalamic area in sleep-wake regulation in rats.  |  Alam, MN., et al. 2009. Brain Res. 1304: 96-104. PMID: 19781535
  2. Electrophilic derivatives of purines as irreversible inhibitors of A1 adenosine receptors.  |  Jacobson, KA., et al. 1989. J Med Chem. 32: 1043-51. PMID: 2709373
  3. Role of endogenous adenosine in postdefibrillation bradyarrhythmia and hemodynamic depression.  |  Wesley, RC. and Belardinelli, L. 1989. Circulation. 80: 128-37. PMID: 2736745
  4. 1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors.  |  Daly, JW., et al. 1985. J Med Chem. 28: 487-92. PMID: 2984420
  5. Probing the adenosine receptor with adenosine and xanthine biotin conjugates.  |  Jacobson, KA., et al. 1985. FEBS Lett. 184: 30-5. PMID: 2985445
  6. Functionalized congeners of 1,3-dipropyl-8-phenylxanthine: potent antagonists for adenosine receptors that modulate membrane adenylate cyclase in pheochromocytoma cells, platelets and fat cells.  |  Ukena, D., et al. 1986. Life Sci. 38: 797-807. PMID: 3005794
  7. A [3H]amine congener of 1,3-dipropyl-8-phenylxanthine. A new radioligand for A2 adenosine receptors of human platelets.  |  Ukena, D., et al. 1986. FEBS Lett. 199: 269-74. PMID: 3009222
  8. [3H]xanthine amine congener of 1,3-dipropyl-8-phenylxanthine: an antagonist radioligand for adenosine receptors.  |  Jacobson, KA., et al. 1986. Proc Natl Acad Sci U S A. 83: 4089-93. PMID: 3012550
  9. Analogues of 1,3-dipropyl-8-phenylxanthine: enhancement of selectivity at A1-adenosine receptors by aryl substituents.  |  Daly, JW., et al. 1986. J Med Chem. 29: 1520-4. PMID: 3016270
  10. [Selectivity of the action of 1,3-dipropyl-8-phenylxanthine on the purine receptors of the intestines].  |  Gmiro, VE., et al. 1988. Farmakol Toksikol. 51: 60-2. PMID: 3191974
  11. Fluorescent A2A and A3 adenosine receptor antagonists as flow cytometry probes.  |  Toti, KS., et al. 2022. Purinergic Signal.. PMID: 35687212
  12. A1- and A2-selective adenosine antagonists: in vivo characterization of cardiovascular effects.  |  Evoniuk, G., et al. 1987. J Pharmacol Exp Ther. 242: 882-7. PMID: 3656117
  13. Adenosine analogs with covalently attached lipids have enhanced potency at A1-adenosine receptors.  |  Jacobson, KA., et al. 1987. FEBS Lett. 225: 97-102. PMID: 3691809

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,3-Dipropyl-8-phenylxanthine, 10 mg

sc-361074
10 mg
$132.00
US: Only available in the US

1,3-Dipropyl-8-phenylxanthine, 50 mg

sc-361074A
50 mg
$551.00
US: Only available in the US