Molecular structure of 1,3-Dimethyluric acid, CAS Number: 944-73-0
1,3-Dimethyluric acid (CAS 944-73-0)
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Alternate Names:
is also known as Oxytheophylline; 1,3-DMUA
CAS Number:
944-73-0
Molecular Weight:
196.16
Molecular Formula:
C7H8N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1,3-Dimethyluric Acid is a metabolite of Caffeine (sc-202514). It has been identified as a peroxynitrite scavenger blocking either peroxynitrite anion-mediated thiol oxidations or phenol/tyrosine nitrations by free radical mechanisms. In experiments involving oxidative protein modifications ofperoxynitrite, 1,3-Dimethyluric Acid was determined to be one of the best inhibitors of phenol nitration. It was also one of the most efficient compounds in inhibiting the nitration of tyrosine residues in BSA.
1,3-Dimethyluric acid (CAS 944-73-0) References
- Nonlinear renal excretion of theophylline and its metabolites, 1-methyluric acid and 1,3-dimethyluric acid, in rats. | Kuh, HJ. and Shim, CK. 1994. Arch Pharm Res. 17: 124-30. PMID: 10319144
- Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of intravenous theophylline in rats: the role of CYP2E1 induction in 1,3-dimethyluric acid formation. | Yu, SY., et al. 2002. J Pharm Pharmacol. 54: 1687-92. PMID: 12542900
- Pharmacokinetics of theophylline in diabetes mellitus rats: induction of CYP1A2 and CYP2E1 on 1,3-dimethyluric acid formation. | Kim, YC., et al. 2005. Eur J Pharm Sci. 26: 114-23. PMID: 15985363
- Associations between CYP2E1 promoter polymorphisms and plasma 1,3-dimethyluric acid/theophylline ratios. | Yoon, Y., et al. 2006. Eur J Clin Pharmacol. 62: 627-31. PMID: 16841220
- Effects of CYP inducers and inhibitors on the pharmacokinetics of intravenous theophylline in rats: involvement of CYP1A1/2 in the formation of 1,3-DMU. | Yang, KH., et al. 2008. J Pharm Pharmacol. 60: 45-53. PMID: 18088504
- Demethylation of theophylline (1,3-dimethylxanthine) to 1-methylxanthine: the first step of an antioxidising cascade. | Santos, PM., et al. 2010. Redox Rep. 15: 138-44. PMID: 20594417
- Nitrosation of N-methyl derivatives of uric acid and their transnitrosation ability to N-acetylcysteine. | Suzuki, T., et al. 2010. Chem Pharm Bull (Tokyo). 58: 1271-5. PMID: 20823616
- Development and validation of a sensitive LC-MS/MS method for the simultaneous quantitation of theophylline and its metabolites in rat plasma. | Chae, JW., et al. 2012. J Chromatogr B Analyt Technol Biomed Life Sci. 889-890: 44-9. PMID: 22365533
- Effect of decursinol angelate on the pharmacokinetics of theophylline and its metabolites in rats. | Chae, JW., et al. 2012. Food Chem Toxicol. 50: 3666-72. PMID: 22771369
- Effect of decursin on the pharmacokinetics of theophylline and its metabolites in rats. | Chae, JW., et al. 2012. J Ethnopharmacol. 144: 248-54. PMID: 22981724
- Age-Associated Theophylline Metabolic Activity Corresponds to the Ratio of 1,3-Dimethyluric Acid to Theophylline in Mice. | Kuroda, Y., et al. 2019. Biol Pharm Bull. 42: 1423-1427. PMID: 31366878
- Isolation, characterization and application of theophylline-degrading Aspergillus fungi. | Zhou, B., et al. 2020. Microb Cell Fact. 19: 72. PMID: 32192512
- Evaluation of the developmental toxicity of theophylline, dimethyluric acid, and methylxanthine metabolites using Xenopus. | Fort, DJ., et al. 1996. Drug Chem Toxicol. 19: 267-78. PMID: 8972234
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1,3-Dimethyluric acid, 100 mg | sc-206240 | 100 mg | $122.00 | |||
1,3-Dimethyluric acid, 250 mg | sc-206240A | 250 mg | $224.00 |