Date published: 2026-4-5

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1,3-Difluorobenzene (CAS 372-18-9)

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CAS Number:
372-18-9
Molecular Weight:
114.09
Molecular Formula:
C6H4F2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,3-difluorobenzene is a difluorobenzene carrying fluoro groups at positions 1 and 3. The presence of fluorine atoms significantly affects the electronic properties of the benzene ring, influencing its reactivity and interactions with other chemical species. It serves as a precursor or intermediate in the synthesis of complex organic molecules, including agrochemicals and materials science precursors. The unique properties of 1,3-difluorobenzene, such as its polarity and ability to form stable π-π interactions, make it a candidate for use in the development of advanced materials, including organic semiconductors, liquid crystals, and fluorinated polymers. 1,3-difluorobenzene can be used as a solvent or standard in various analytical techniques, including nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS). Its volatility and inertness also make it suitable for use in gas chromatography (GC) as a solvent or carrier.


1,3-Difluorobenzene (CAS 372-18-9) References

  1. Novel synthesis of desymmetrized resorcinol derivatives: aryl fluoride displacement on deactivated substrates.  |  Kim, A., et al. 2006. J Org Chem. 71: 2170-2. PMID: 16497012
  2. Photodissociation dynamics of C6HxF6-x (x = 1-4) at 193 nm.  |  Lin, MF., et al. 2005. J Phys Chem B. 109: 8344-9. PMID: 16851978
  3. Iridium derivatives of fluorinated aromatics by C-H activation: isolation of classical and non-classical hydrides.  |  Salomon, MA., et al. 2008. Dalton Trans. 5197-206. PMID: 18813374
  4. The effect of perfluorination on the aromaticity of benzene and heterocyclic six-membered rings.  |  Wu, JI., et al. 2009. J Phys Chem A. 113: 6789-94. PMID: 19472981
  5. A mechanistic investigation of carbon-hydrogen bond stannylation: synthesis and characterization of nickel catalysts.  |  Johnson, SA., et al. 2012. Dalton Trans. 41: 8135-43. PMID: 22495289
  6. Molecular thermal hysteresis in helix-dimer formation of sulfonamidohelicene oligomers in solution.  |  Shigeno, M., et al. 2013. Chemistry. 19: 10226-34. PMID: 23775763
  7. Regioselectivity of cytochrome P-450 catalyzed hydroxylation of fluorobenzenes predicted by calculated frontier orbital substrate characteristics.  |  Rietjens, IM., et al. 1993. Biochemistry. 32: 4801-12. PMID: 8490024

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,3-Difluorobenzene, 10 g

sc-222970
10 g
$80.00

1,3-Difluorobenzene, 100 g

sc-222970A
100 g
$144.00