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1,3-Difluoro-2-propanol (CAS 453-13-4)

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Application:
1,3-Difluoro-2-propanol is used in the synthesis of 1,3-difluoroacetone
CAS Number:
453-13-4
Molecular Weight:
96.08
Molecular Formula:
FCH2CH(OH)CH2F
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,3-Difluoro-2-propanol, a fluorinated alcohol, has garnered significant interest in scientific research due to its unique chemical properties and versatile applications. As a fluorinated compound, it exhibits enhanced stability and resistance to metabolic degradation compared to non-fluorinated analogs, making it valuable in various research areas. One of its notable applications is as a building block in the synthesis of fluorinated organic molecules, where its difluoromethyl group serves as a key functional group for introducing fluorine atoms into complex molecular structures. Additionally, 1,3-Difluoro-2-propanol has been utilized as a solvent in chemical reactions, particularly in processes requiring controlled fluorination or as a reaction medium for fluorine-containing substrates. Its use as a solvent exploits its unique solvation properties and ability to stabilize reactive intermediates, facilitating the synthesis of fluorinated compounds with specific stereochemical and regiochemical characteristics. Moreover, researchers have investigated its potential as a chiral auxiliary in asymmetric synthesis, leveraging its chiral center to induce stereocontrol in various chemical transformations. Overall, 1,3-Difluoro-2-propanol continues to be a valuable tool in synthetic chemistry research, contributing to the development of new fluorine-containing compounds with diverse applications in materials science, pharmaceuticals, and agrochemicals.


1,3-Difluoro-2-propanol (CAS 453-13-4) References

  1. The mode of toxic action of the pesticide gliftor: the metabolism of 1,3-difluoroacetone to (-)-erythro-fluorocitrate.  |  Menon, KI., et al. 2001. J Biochem Mol Toxicol. 15: 47-54. PMID: 11170315
  2. Csp3-F bond activation by nucleophilic attack of the {Pt2S2} core assisted by non-covalent interactions.  |  Nova, A., et al. 2008. Chem Commun (Camb). 3130-2. PMID: 18594718
  3. The biochemical toxicology of 1,3-difluoro-2-propanol, the major ingredient of the pesticide gliftor: the potential of 4-methylpyrazole as an antidote.  |  Feldwick, MG., et al. 1998. J Biochem Mol Toxicol. 12: 41-52. PMID: 9414486
  4. 1, 3-Difluoro-2-Propanol: a Potential Replacement for 1080 in Fauna Management Programs in Australia[J].  |  Mead R J, Feldwick M G, Bunn J T. 1991. Wildlife research,., 18(1):: 27-37.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,3-Difluoro-2-propanol, 1 g

sc-222969
1 g
$36.00