Date published: 2025-9-14

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1,3-Dichloropropene (CAS 542-75-6)

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Alternate Names:
3-Chloroallyl Chloride
CAS Number:
542-75-6
Molecular Weight:
110.97
Molecular Formula:
C3H4Cl2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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This compound typically exists as a colorless liquid under standard conditions and possesses a sweet, chloroform-like odor. It is known for its volatility and solubility characteristics, which are influenced by the presence of chlorine atoms in its structure. 1,3-Dichloropropene is primarily used in the chemical industry as an intermediate in the synthesis of other chemicals, and it also has applications in agriculture. One of the primary research applications of 1,3-Dichloropropene has been in the agricultural sector. It has been extensively studied and used as a pre-planting soil fumigant. The compound is effective against a wide range of soil-borne pests, including nematodes, fungi, and weeds. Its mode of action involves volatilizing into the soil and disrupting the biological functions of target pests, thereby protecting crops and improving yield. Research in this area focuses on optimizing its efficacy while minimizing environmental and non-target organism impacts. In chemical synthesis, 1,3-Dichloropropene serves as an intermediate for the production of other important chemicals. Its reactivity, particularly in the presence of other reagents, allows for the creation of various derivatives that have further applications in different industrial processes. Studies have explored its use in synthesizing polymers, and other organic compounds. The focus of such research often includes improving reaction conditions, yields, and developing more environmentally friendly processes.


1,3-Dichloropropene (CAS 542-75-6) References

  1. 1,3-dichloropropene distribution and emission after gelatin capsule formulation application.  |  Wang, Q., et al. 2010. J Agric Food Chem. 58: 361-5. PMID: 19908833
  2. Mechanism of 1,3-dichloropropene-induced rat liver carcinogenesis.  |  Klaunig, JE., et al. 2015. Toxicol Sci. 143: 6-15. PMID: 25354764
  3. Mechanisms for 1,3-Dichloropropene Dissipation in Biochar-Amended Soils.  |  Wang, Q., et al. 2016. J Agric Food Chem. 64: 2531-40. PMID: 26954066
  4. Effects of fumigation with 1,3-dichloropropene on soil enzyme activities and microbial communities in continuous-cropping soil.  |  Zhang, D., et al. 2019. Ecotoxicol Environ Saf. 169: 730-736. PMID: 30502523
  5. Groundwater monitoring for 1,3-dichloropropene in high fumigant use areas of North America and Europe.  |  van Wesenbeeck, IJ. and Knowles, S. 2019. Pest Manag Sci. 75: 2278-2282. PMID: 30843340
  6. The association between 1,3-dichloropropene and asthma emergency department visits in California, USA from 2005 to 2011: a bidirectional-symmetric case crossover study.  |  Gharibi, H., et al. 2020. J Asthma. 57: 601-609. PMID: 30938205
  7. Metabolic Basis for Nonlinearity in 1,3-Dichloropropene Toxicokinetics and Use in Setting a Kinetically-derived Maximum Inhalation Exposure Concentration in Mice.  |  Bartels, MJ., et al. 2020. Toxicol Sci. 174: 16-24. PMID: 31808915
  8. 1,3-Dichloropropene and chloropicrin emission reduction using a flexible CuInS2/ZnS:Al-TiO2 photocatalytic film.  |  Yan, L., et al. 2021. Environ Sci Pollut Res Int. 28: 6980-6989. PMID: 33025439
  9. Weight of evidence analysis of the tumorigenic potential of 1,3-dichloropropene supports a threshold-based risk assessment.  |  Yan, ZJ., et al. 2020. Crit Rev Toxicol. 50: 836-860. PMID: 33528302
  10. Peer review of a cancer weight of evidence assessment based on updated toxicokinetics, genotoxicity, and carcinogenicity data for 1,3-dichloropropene using a blinded, virtual panel of experts.  |  Hays, SM., et al. 2020. Crit Rev Toxicol. 50: 861-884. PMID: 33528305
  11. A reassessment of the fungicidal efficacy of 1,3-dichloropropene, chloropicrin, and metam potassium against Macrophomina phaseolina in strawberry.  |  Baggio, JS., et al. 2022. Pest Manag Sci. 78: 3416-3423. PMID: 35544358
  12. An Ecologic Study of the Association between 1,3-Dichloropropene and Pancreatic Cancer.  |  McGwin, G. and Griffin, RL. 2022. Cancers (Basel). 15: PMID: 36612145

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,3-Dichloropropene, 100 g

sc-237723
100 g
$77.00