Date published: 2025-9-30

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1,3-Di-Boc-2-(2-hydroxyethyl)guanidine (CAS 215050-11-6)

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Alternate Names:
Tert-butyl N-[N′-(2-hydroxyethyl)-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]carbamate
Application:
1,3-Di-Boc-2-(2-hydroxyethyl)guanidine is a guanidinylation reagent
CAS Number:
215050-11-6
Purity:
≥99%
Molecular Weight:
303.35
Molecular Formula:
C13H25N3O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,3-Di-Boc-2-(2-hydroxyethyl)guanidine, also known as Boc-Gly-OH, is a versatile organic compound extensively employed in the synthesis of peptides and proteins. As a dipeptide building block, it plays a role in both enzymatic and chemical methods of peptide and protein synthesis. Its significance extends to various applications within the field. 1,3-Di-Boc-2-(2-hydroxyethyl)guanidine finds widespread utilization in peptide and protein synthesis, catering to research endeavors. It serves as a fundamental component in the creation of peptides.Functioning as a peptide building block, 1,3-Di-Boc-2-(2-hydroxyethyl)guanidine facilitates the formation of peptide bonds between amino acids. When combined with a base such as sodium hydroxide, it undergoes a reaction with the amino acid, resulting in the formation of a stable peptide bond. This reaction, catalyzed by the base, yields a product resilient to acidic and basic conditions.


1,3-Di-Boc-2-(2-hydroxyethyl)guanidine (CAS 215050-11-6) References

  1. Oligocarbonate molecular transporters: oligomerization-based syntheses and cell-penetrating studies.  |  Cooley, CB., et al. 2009. J Am Chem Soc. 131: 16401-3. PMID: 19860416
  2. De novo designed protein transduction domain mimics from simple synthetic polymers.  |  Tezgel, AÖ., et al. 2011. Biomacromolecules. 12: 3078-83. PMID: 21714570
  3. Design of aromatic-containing cell-penetrating peptide mimics with structurally modified π electronics.  |  deRonde, BM., et al. 2015. Chemistry. 21: 3013-9. PMID: 25537501
  4. Anionic Lipid Content Presents a Barrier to the Activity of ROMP-Based Synthetic Mimics of Protein Transduction Domains (PTDMs).  |  Lis, M., et al. 2016. Langmuir. 32: 5946-54. PMID: 27182683
  5. Bacterial membrane permeability of antimicrobial polymethacrylates: Evidence for a complex mechanism from super-resolution fluorescence imaging.  |  Michl, TD., et al. 2020. Acta Biomater. 108: 168-177. PMID: 32179195
  6. Guanidine-based polycarbonate hydrogels: from metal-free ring-opening polymerization to reversible self-assembling properties  |  Christophe Bartolini,a Laetitia Mespouille,*a Ingrid Verbruggen,b Rudolph Willemb and Philippe Duboisa. 2011. soft Matter,. 7: 9628-9637.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,3-Di-Boc-2-(2-hydroxyethyl)guanidine, 1 g

sc-251579
1 g
$97.00