Molecular structure of 1-(3-Chlorophenyl)piperazine, CAS Number: 6640-24-0
1-(3-Chlorophenyl)piperazine (CAS 6640-24-0)
Alternate Names:
1-(m-Chlorophenyl)piperazine
Application:
1-(3-Chlorophenyl)piperazine is a major circulating metabolite in humans
CAS Number:
6640-24-0
Molecular Weight:
196.68
Molecular Formula:
C10H13ClN2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1-(3-Chlorphenyl)piperazine (m-CPP), resulting from N-dealkylation of Trazodone, is a major circulating metabolite in humans. It is common to several antidepressants including Trazodone, Nefazodone, and Etoperidone.
1-(3-Chlorophenyl)piperazine (CAS 6640-24-0) References
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- Creation and application of psychoactive designer drugs data library using liquid chromatography with photodiode array spectrophotometry detector and gas chromatography-mass spectrometry. | Takahashi, M., et al. 2009. Talanta. 77: 1245-72. PMID: 19084633
- Detection of 1-benzylpiperazine, 1-(3-trifluoromethylphenyl)-piperazine, and 1-(3-chlorophenyl)-piperazine in 3,4-methylenedioxymethamphetamine-positive urine samples. | Dickson, AJ., et al. 2010. J Anal Toxicol. 34: 464-9. PMID: 21819791
- Anxiogenic-like effect of infusing 1-(3-chlorophenyl) piperazine (mCPP) into the hippocampus. | Whitton, P. and Curzon, G. 1990. Psychopharmacology (Berl). 100: 138-40. PMID: 2296623
- Improvement of the isolation-induced social behavioural deficit involves activation of the 5-HT1B receptors. | Frances, H., et al. 1990. Prog Neuropsychopharmacol Biol Psychiatry. 14: 91-102. PMID: 2300682
- Chronic but not acute antidepressants interfere with serotonin (5-HT1B) receptors. | Frances, H. and Khidichian, F. 1990. Eur J Pharmacol. 179: 173-6. PMID: 2364979
- Anxiogenic-like effects of mCPP and TFMPP in animal models are opposed by 5-HT1C receptor antagonists. | Kennett, GA., et al. 1989. Eur J Pharmacol. 164: 445-54. PMID: 2767117
- Evidence that hypophagia induced by mCPP and TFMPP requires 5-HT1C and 5-HT1B receptors; hypophagia induced by RU 24969 only requires 5-HT1B receptors. | Kennett, GA. and Curzon, G. 1988. Psychopharmacology (Berl). 96: 93-100. PMID: 2906446
- Cananga odorata essential oil reverses the anxiety induced by 1-(3-chlorophenyl) piperazine through regulating the MAPK pathway and serotonin system in mice. | Zhang, N., et al. 2018. J Ethnopharmacol. 219: 23-30. PMID: 29545208
- Effects of adrenodemedullation and adrenalectomy on the 5-HT2 receptor agonists DOI-and mCPP-induced hypophagia in rats. | Yamada, J., et al. 1996. Neurosci Lett. 209: 113-6. PMID: 8761995
- The anticonvulsant action of fluoxetine in substantia nigra is dependent upon endogenous serotonin. | Pasini, A., et al. 1996. Brain Res. 724: 84-8. PMID: 8816259
- Effects of the 5-HT2C/2B receptor agonist 1-(3-chlorophenyl) piperazine on plasma glucose levels of rats. | Sugimoto, Y., et al. 1996. Eur J Pharmacol. 307: 75-80. PMID: 8831107
Inhibitor of:
SR-2A, and TCP-1 ε.Activator of:
SR-2B, and SR-2C.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-(3-Chlorophenyl)piperazine, 5 mg | sc-206098 | 5 mg | $330.00 | |||
| US: Only available in the US | ||||||