Date published: 2025-10-3

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1,3,5-Trioxane (CAS 110-88-3)

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Alternate Names:
Metaformaldehyde
CAS Number:
110-88-3
Molecular Weight:
90.08
Molecular Formula:
C3H6O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,3,5-Trioxane is a synthetic organic compound known primarily for its role in chemical synthesis and research applications, particularly as a precursor in the production of other complex molecules. Its mechanism of action involves participating in various chemical reactions where its symmetrical, ring-shaped structure, composed of three interconnected oxygen atoms, makes it uniquely reactive. This reactivity is harnessed in the laboratory to facilitate the formation of more complex structures, serving as a building block in organic synthesis. In research applications, 1,3,5-trioxane is often utilized in polymerization reactions due to its ability to form polymers with desirable properties, which are studied for their potential applications in materials science. The compound′s stability under a range of conditions, combined with its reactivity, makes it an invaluable tool in the exploration of chemical reactions and the development of novel synthetic pathways, contributing significantly to advancements in the field of chemistry.


1,3,5-Trioxane (CAS 110-88-3) References

  1. Quantitative NMR assay for aspirin, phenacetin, and caffeine mixtures with 1,3,5-trioxane as internal standard.  |  Eberhart, ST., et al. 1986. J Pharm Biomed Anal. 4: 147-54. PMID: 16867610
  2. Profiling of volatile impurities in tetramethylenedisulfotetramine (TETS) for synthetic-route determination.  |  Fraga, CG., et al. 2011. Forensic Sci Int. 210: 164-9. PMID: 21444165
  3. High-Temperature Experimental and Theoretical Study of the Unimolecular Dissociation of 1,3,5-Trioxane.  |  Alquaity, AB., et al. 2015. J Phys Chem A. 119: 6594-601. PMID: 25978148
  4. Rhodium(II)-Catalyzed Annulation of Azavinyl Carbenes Through Ring-Expansion of 1,3,5-Trioxane: Rapid Access to Nine-Membered 1,3,5,7-Trioxazonines.  |  Pospech, J., et al. 2015. Chem Asian J. 10: 2624-30. PMID: 26247492
  5. Corrigendum: Rhodium(II)-Catalyzed Annulation of Azavinyl Carbenes Through Ring-Expansion of 1,3,5-Trioxane: Rapid Access to Nine-Membered 1,3,5,7-Trioxazonines.  |  Pospech, J., et al. 2016. Chem Asian J. 11: 2085. PMID: 27439565
  6. Maximizing Ether Oxygen Content in Polymers for Membrane CO2 Removal from Natural Gas.  |  Liu, J., et al. 2019. ACS Appl Mater Interfaces. 11: 10933-10940. PMID: 30794744
  7. Simultaneous Conversion of C5 and C6 Sugars into Methyl Levulinate with the Addition of 1,3,5-Trioxane.  |  Lyu, X., et al. 2019. ChemSusChem. 12: 4400-4404. PMID: 31419072
  8. LiDFOB Initiated In Situ Polymerization of Novel Eutectic Solution Enables Room-Temperature Solid Lithium Metal Batteries.  |  Wu, H., et al. 2020. Adv Sci (Weinh). 7: 2003370. PMID: 33304769
  9. A rapid compression machine coupled with time-resolved molecular beam mass spectrometry for gas-phase kinetics studies.  |  Kang, S., et al. 2021. Rev Sci Instrum. 92: 084103. PMID: 34470393
  10. Novel polymeric acidic ionic liquids as green catalysts for the preparation of polyoxymethylene dimethyl ethers from the acetalation of methylal with trioxane.  |  Song, H., et al. 2019. RSC Adv. 9: 40662-40669. PMID: 35542668
  11. [Experimental studies of toxic effects of 1,3,5-trioxane and 1,3-dioxolane. I. Acute toxic effect].  |  Czajkowska, T., et al. 1987. Med Pr. 38: 184-90. PMID: 3670042
  12. The disposition and metabolism of 1,3,5-[U-14C]trioxane in male Wistar albino rats.  |  Ligocka, D., et al. 1998. Arch Toxicol. 72: 303-8. PMID: 9630017

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,3,5-Trioxane, 25 g

sc-237741
25 g
$21.00

1,3,5-Trioxane, 500 g

sc-237741A
500 g
$26.00