Date published: 2026-4-5

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1-(3,4-Dichlorophenyl)piperazine (CAS 57260-67-0)

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CAS Number:
57260-67-0
Molecular Weight:
231.12
Molecular Formula:
C10H12Cl2N2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1-(3,4-Dichlorophenyl)piperazine functions as a serotonin receptor agonist in experiment. It acts by binding to and activating serotonin receptors in the central nervous system, targeting the 5-HT1A and 5-HT1B receptor subtypes. This interaction modulates the release of neurotransmitters such as dopamine, norepinephrine, and serotonin, leading to downstream effects on neuronal signaling and synaptic transmission. By targeting serotonin receptors, 1-(3,4-Dichlorophenyl)piperazine can be used to investigate the role of serotonin in various physiological and behavioral processes. Its mechanism of action involves the modulation of intracellular signaling pathways and gene expression, influencing neuronal excitability and synaptic plasticity. 1-(3,4-Dichlorophenyl)piperazine′s ability to selectively activate serotonin receptors makes it useful in studying the complex interplay of neurotransmitters in the central nervous system.


1-(3,4-Dichlorophenyl)piperazine (CAS 57260-67-0) References

  1. Cyanoindole derivatives as highly selective dopamine D(4) receptor partial agonists: solid-phase synthesis, binding assays, and functional experiments.  |  Hübner, H., et al. 2000. J Med Chem. 43: 4563-9. PMID: 11087581
  2. (Phenylpiperazinyl-butyl)oxindoles as selective 5-HT7 receptor antagonists.  |  Volk, B., et al. 2008. J Med Chem. 51: 2522-32. PMID: 18361484
  3. Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors.  |  Mosley, CA., et al. 2009. Bioorg Med Chem. 17: 6463-80. PMID: 19648014
  4. Chemiluminescence detection of piperazine designer drugs and related compounds using tris(2,2'-bipyridine)ruthenium(III).  |  Waite, RJ., et al. 2013. Talanta. 116: 1067-72. PMID: 24148517
  5. Synthesis and Anti-inflammatory Performance of Newly Cyclizine Derivatives on Adult Male Wistar Rats.  |  Ahmadi, A., et al. 2012. Iran J Pharm Res. 11: 1027-37. PMID: 24250533
  6. Structural basis for rational design of inhibitors targeting Trypanosoma cruzi sterol 14α-demethylase: two regions of the enzyme molecule potentiate its inhibition.  |  Friggeri, L., et al. 2014. J Med Chem. 57: 6704-17. PMID: 25033013
  7. Iridium-Catalyzed Asymmetric Ring-Opening of Oxabenzonorbornadienes with N-Substituted Piperazine Nucleophiles.  |  Yang, W., et al. 2015. Molecules. 20: 21103-24. PMID: 26633315
  8. Synthesis and biological evaluation of a series of novel pyridinecarboxamides as potential multi-receptor antipsychotic drugs.  |  Xu, M., et al. 2018. Bioorg Med Chem Lett. 28: 606-611. PMID: 29395980
  9. Design, synthesis and docking study of 4-arylpiperazine carboxamides as monoamine neurotransmitters reuptake inhibitors.  |  Paudel, S., et al. 2018. Bioorg Med Chem. 26: 4127-4135. PMID: 30007567
  10. Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors.  |  Deplano, A., et al. 2019. J Enzyme Inhib Med Chem. 34: 562-576. PMID: 30688118
  11. A Glutamate N-Methyl-d-Aspartate (NMDA) Receptor Subunit 2B-Selective Inhibitor of NMDA Receptor Function with Enhanced Potency at Acidic pH and Oral Bioavailability for Clinical Use.  |  Myers, SJ., et al. 2021. J Pharmacol Exp Ther. 379: 41-52. PMID: 34493631
  12. Antinociceptive and Antiallodynic Activity of Some 3-(3-Methylthiophen-2-yl)pyrrolidine-2,5-dione Derivatives in Mouse Models of Tonic and Neuropathic Pain.  |  Dziubina, A., et al. 2022. Int J Mol Sci. 23: PMID: 35409413
  13. Synthesis, Docking Studies and Pharmacological Evaluation of Serotoninergic Ligands Containing a 5-Norbornene-2-Carboxamide Nucleus.  |  Sparaco, R., et al. 2022. Molecules. 27: PMID: 36235029

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1-(3,4-Dichlorophenyl)piperazine, 5 g

sc-237441
5 g
$142.00