1,3,4,5-Tetra-O-benzyl-D-glucitol (CAS 14233-48-8)

1,3,4,5-Tetra-O-benzyl-D-glucitol, commonly known as tetra-O-benzyl-D-glucitol (TBG), is a versatile compound extensively utilized in carbohydrate chemistry research. Its mechanism of action lies in its ability to serve as a protecting group for the hydroxyl (OH) functional groups of glucose units in oligosaccharides. By selectively masking these OH groups, TBG prevents undesired reactions at specific positions during glycosylation processes, allowing for the synthesis of complex carbohydrates with precise regio- and stereochemistry. TBG has been employed in the synthesis of various glycoconjugates, glycopeptides, and oligosaccharides, enabling researchers to explore carbohydrate-mediated biological interactions. Additionally, TBG plays a crucial role in the development of carbohydrate-based materials, such as glycan microarrays and carbohydrate-modified surfaces, for applications in drug discovery, diagnostics, and vaccine development. Its widespread use underscores its significance in carbohydrate chemistry research, facilitating the synthesis of structurally diverse carbohydrates and contributing to advancements in understanding carbohydrate-protein interactions and their implications in various biological processes.