Date published: 2026-5-1

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1-(2-Hydroxyethyl)-4-methylpiperazine (CAS 5464-12-0)

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Alternate Names:
4-Methylpiperazine-1-ethanol
CAS Number:
5464-12-0
Molecular Weight:
144.22
Molecular Formula:
C7H16N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1-(2-Hydroxyethyl)-4-methylpiperazine is used a viscosity control agent and serves as an intermediate in the production of other chemicals. The synthesis of 1-(2-Hydroxyethyl)-4-methylpiperazine can be achieved through the interaction of ethylene oxide with amines, or by quaternization of diethanolamine with chloroethane. Within the industrial realm, it is used in ion exchange resins and to control the viscosity of drilling fluids.


1-(2-Hydroxyethyl)-4-methylpiperazine (CAS 5464-12-0) References

  1. Antibacterial and Anti-Quorum Sensing Molecular Composition Derived from Quercus cortex (Oak bark) Extract.  |  Deryabin, DG. and Tolmacheva, AA. 2015. Molecules. 20: 17093-108. PMID: 26393551
  2. Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4.  |  Charvin, D., et al. 2017. J Med Chem. 60: 8515-8537. PMID: 28902994
  3. Identification of Pak1 inhibitors using water thermodynamic analysis.  |  Biswal, J., et al. 2020. J Biomol Struct Dyn. 38: 13-31. PMID: 30661460
  4. Spontaneous conversion of O-tosylates of 2-(piperazin-1-yl)ethanols into chlorides during classical tosylation procedure.  |  Kurteva, VB., et al. 2019. R Soc Open Sci. 6: 181840. PMID: 30891294
  5. pH- and Temperature-responsive Hydrogels Based on Tertiary Amine-modified Polypeptides for Stimuli-responsive Drug Delivery.  |  Lin, Z., et al. 2023. Chem Asian J. 18: e202300021. PMID: 36856525

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1-(2-Hydroxyethyl)-4-methylpiperazine, 1 g

sc-272875
1 g
$32.00

1-(2-Hydroxyethyl)-4-methylpiperazine, 5 g

sc-272875A
5 g
$58.00