Date published: 2025-12-18

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1,2-Hexanediol (CAS 6920-22-5)

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Alternate Names:
1,2-Dihydroxyhexane; 1,2-Hexyleneglycol; 5,6-Dihydroxyhexane; DL-1,2-Hexanediol
CAS Number:
6920-22-5
Purity:
≥96%
Molecular Weight:
118.17
Molecular Formula:
C6H14O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,2-Hexanediol is a chemical compound that functions as a solvent and viscosity decreasing agent. It acts by interacting with other substances to dissolve them or reduce their thickness, allowing for easier mixing and manipulation of experimental samples. At the molecular level, 1,2-Hexanediol disrupts the intermolecular forces between particles, leading to a decrease in viscosity and an increase in the solubility of other substances. This enables more efficient dispersion and blending of components in experimental formulations. 1,2-Hexanediol can act as a stabilizer, helping to maintain the integrity and consistency of experimental mixtures over time. Its mode of action involves forming hydrogen bonds with other molecules, altering their physical properties and enhancing the overall performance of experimental solutions.


1,2-Hexanediol (CAS 6920-22-5) References

  1. Adjusting selectivity in micellar electrokinetic capillary chromatography with 1,2-hexanediol.  |  Allen, DJ., et al. 1999. Electrophoresis. 20: 100-10. PMID: 10065965
  2. Safety of a preservative system containing 1,2-hexanediol and caprylyl glycol.  |  Levy, SB., et al. 2009. Cutan Ocul Toxicol. 28: 23-4. PMID: 19514921
  3. The influence of alkane chain length on the skin irritation potential of 1,2-alkanediols.  |  Lee, E., et al. 2011. Int J Cosmet Sci. 33: 421-5. PMID: 21585401
  4. Synergistic effect of 1,4-cyclohexanediol and 1,2-hexanediol on percutaneous absorption and penetration of metronidazole.  |  Li, N., et al. 2011. Int J Pharm. 415: 169-74. PMID: 21669264
  5. Effect of hydrocarbon chain length in 1,2-alkanediols on percutaneous absorption of metronidazole: toward development of a general vehicle for controlled release.  |  Li, N., et al. 2014. AAPS PharmSciTech. 15: 354-63. PMID: 24395400
  6. Effect of hydroxyl groups and rigid structure in 1,4-cyclohexanediol on percutaneous absorption of metronidazole.  |  Zhang, Y., et al. 2014. AAPS PharmSciTech. 15: 973-80. PMID: 24821219
  7. Food-grade antimicrobials potentiate the antibacterial activity of 1,2-hexanediol.  |  Yogiara, ., et al. 2015. Lett Appl Microbiol. 60: 431-9. PMID: 25631558
  8. Influence of 1,2-alkanediols on the structure of their intercalates with strontium phenylphosphonate solved by molecular simulation and experimental methods.  |  Svoboda, J., et al. 2016. J Mol Model. 22: 143. PMID: 27245062
  9. Phototoxicity and chronic toxicity of methyl paraben and 1,2-hexanediol in Daphnia magna.  |  Lee, J., et al. 2017. Ecotoxicology. 26: 81-89. PMID: 27866342
  10. Evaporation-Triggered Segregation of Sessile Binary Droplets.  |  Li, Y., et al. 2018. Phys Rev Lett. 120: 224501. PMID: 29906161
  11. Rapid chemical clearing of white matter in the post-mortem human brain by 1,2-hexanediol delipidation.  |  Inoue, M., et al. 2019. Bioorg Med Chem Lett. 29: 1886-1890. PMID: 31160178
  12. Hydrophilic and organophilic pervaporation of industrially important α,β and α,ω-diols.  |  Chaudhari, S., et al. 2021. RSC Adv. 11: 9274-9284. PMID: 35423423
  13. Elution with 1,2-Hexanediol Enables Coupling of ICPMS with Reversed-Pase Liquid Chromatography under Standard Conditions.  |  Lajin, B., et al. 2022. Anal Chem. 94: 8802-8810. PMID: 35666989
  14. Determination of Phosphoethanolamine in Urine with HPLC-ICPMS/MS Using 1,2-Hexanediol as a Chromatographic Eluent.  |  Lajin, B. and Goessler, W. 2023. Anal Chem. 95: 8706-8710. PMID: 37216218

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,2-Hexanediol, 10 g

sc-237688
10 g
$29.00