Date published: 2026-5-2

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1,2-Distearoyl-sn-glycerol (CAS 10567-21-2)

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Alternate Names:
L-1,2-Distearin; 1,2-Dioctadecanoyl-sn-glycerol
CAS Number:
10567-21-2
Molecular Weight:
625.03
Molecular Formula:
C39H76O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,2-Distearoyl-sn-glycerol is a lipid molecule extensively used in the field of lipidomics and for the formulation of liposomes and lipid-based nanoparticles. As a diacylglycerol with two stearic acid chains, it is instrumental in studying lipid bilayer properties and the assembly of membrane mimicking systems. Researchers exploit this compound to investigate membrane fluidity, phase transitions, and the interaction of proteins with lipid membranes, which are critical for understanding cellular signaling and membrane dynamics. In addition, 1,2-Distearoyl-sn-glycerol is a key component in the creation of stable liposomal preparations, which are used to encapsulate various substances to study their transport and delivery within biological systems.


1,2-Distearoyl-sn-glycerol (CAS 10567-21-2) References

  1. Structure and functional properties of diacylglycerols in membranes.  |  Goñi, FM. and Alonso, A. 1999. Prog Lipid Res. 38: 1-48. PMID: 10396601
  2. Mitigation of 3-Monochloro-1,2-propanediol Ester Formation by Radical Scavengers.  |  Zhang, H., et al. 2016. J Agric Food Chem. 64: 5887-92. PMID: 27396990
  3. Modifying Cationic Liposomes with Cholesteryl-PEG Prevents Their Aggregation in Human Urine and Enhances Cellular Uptake by Bladder Cancer Cells.  |  Nakamura, T., et al. 2017. Biol Pharm Bull. 40: 234-237. PMID: 28154264
  4. Puerarin inhibited 3-chloropropane-1,2-diol fatty acid esters formation by reacting with glycidol and glycidyl esters.  |  Wang, R., et al. 2021. Food Chem. 358: 129843. PMID: 33915425
  5. Effect of liposome surface modification with water-soluble phospholipid polymer chain-conjugated lipids on interaction with human plasma proteins.  |  Adler, A., et al. 2022. J Mater Chem B. 10: 2512-2522. PMID: 34617092
  6. Microfluidic production of mRNA-loaded lipid nanoparticles for vaccine applications.  |  Lopes, C., et al. 2022. Expert Opin Drug Deliv. 19: 1381-1395. PMID: 36223174
  7. Design and synthesis of 4-azido-phosphatidylinositol as a potential probe for metabolic engineering of glycosylphosphatidylinositol on cells.  |  Craig, KC. and Guo, Z. 2022. J Carbohydr Chem. 41: 238-248. PMID: 36540620
  8. Physical behavior of the mixed chain diacylglycerol, 1-stearoyl-2-oleoyl-sn-glycerol: difficulties in chain packing produced marked polymorphism.  |  Di, L. and Small, DM. 1993. J Lipid Res. 34: 1611-23. PMID: 8228644
  9. The effects of chloride and the antioxidant capacity of fried foods on 3-chloro-1, 2-propanediol esters and glycidyl esters during long-term deep-frying.  |  Huang, Zhaoxian, et al. 2021. Lwt. 145: 111511.
  10. Neutral polyphosphocholine-modified liposomes as boundary superlubricants.  |  Lin, Weifeng, et al. 2022. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 648: 129218.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,2-Distearoyl-sn-glycerol, 250 mg

sc-220522
250 mg
$119.00

1,2-Distearoyl-sn-glycerol, 1 g

sc-220522A
1 g
$265.00