1,2-Distearoyl-sn-glycero-3-phospho-L-serine sodium salt (CAS 321595-13-5)

1,2-Distearoyl-sn-glycero-3-phospho-L-serine sodium salt, commonly known as DSPS-Na, is a synthetic phospholipid that plays a pivotal role in the study of membrane biophysics. Featuring a glycerol backbone with two stearic acid chains attached at the sn-1 and sn-2 positions, DSPS-Na forms highly rigid and less fluid lipid bilayers, mimicking certain characteristics of biological membranes. The molecule′s headgroup, phospho-L-serine, carries a negative charge neutralized by sodium, making it particularly useful for recreating the anionic surface of cell membranes, especially those of the inner leaflet. In research, DSPS-Na is extensively used to explore protein-lipid interactions, the role of lipid composition in membrane dynamics, and the effects of membrane charge on cellular processes such as signaling and vesicle trafficking. This phospholipid aids in understanding the fundamental mechanisms by which membranes influence cellular behavior, without direct implications in therapeutic or pharmaceutical applications, thereby enriching our knowledge of cellular structure and function purely from a biophysical perspective.