Molecular structure of 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, CAS Number: 4004-05-1
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (CAS 4004-05-1)
See product citations (3)
Alternate Names:
DOPE
Application:
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine is a membrane phospholipid emulsifier to improve transfection of DNA
CAS Number:
4004-05-1
Purity:
≥98%
Molecular Weight:
744.0
Molecular Formula:
C41H78NO8P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) is a phospholipid emulsifier that has been used for improved DNA-liposome complex transport across membranes. Commonly used with the cationic emulsifier DOTAP (3-trimethylammonium-propane)(sc-202589), 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine reduces the toxic effects of DOTAP alone and may act to have a high DNA trapping efficiency of 89% at a DOTAP:DOPE ratio of 2:1 in emulsions. The compound is ideal for use in gene transfer studies for both conditions with serum, in vivo, and without.
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (CAS 4004-05-1) References
- Optimization of lipid composition in cationic emulsion as in vitro and in vivo transfection agents. | Kim, TW., et al. 2001. Pharm Res. 18: 54-60. PMID: 11336353
- Chemical hydrolysis of DOTAP and DOPE in a liposomal environment. | Vernooij, EA., et al. 2002. J Control Release. 79: 299-303. PMID: 11853940
- Determination of L(alpha)-H(II) phase transition temperature for 1,2-dioleoyl-sn-glycero-3-phosphatidylethanolamine. | Toombes, GE., et al. 2002. Biophys J. 82: 2504-10. PMID: 11964238
- Physicochemical characterization and gene transfection efficiency of lipid emulsions with various co-emulsifiers. | Hung, CF., et al. 2005. Int J Pharm. 289: 197-208. PMID: 15652212
- A novel cationic liposome reagent for efficient transfection of mammalian cells. | Gao, X. and Huang, L. 1991. Biochem Biophys Res Commun. 179: 280-5. PMID: 1883357
- The interaction energies of cholesterol and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine in spread mixed monolayers at the air-water interface. | Savva, M. and Acheampong, S. 2009. J Phys Chem B. 113: 9811-20. PMID: 19569618
- Tumor-targeting and pH-sensitive lipoprotein-mimic nanocarrier for targeted intracellular delivery of paclitaxel. | Chen, C., et al. 2015. Int J Pharm. 480: 116-27. PMID: 25615984
- Association between cationic liposomes and low molecular weight hyaluronic acid. | Gasperini, AA., et al. 2015. Langmuir. 31: 3308-17. PMID: 25730494
- Dequalinium-based functional nanosomes show increased mitochondria targeting and anticancer effect. | Bae, Y., et al. 2018. Eur J Pharm Biopharm. 124: 104-115. PMID: 29305141
- High-Speed Microscopy of Diffusion in Pore-Spanning Lipid Membranes. | Spindler, S., et al. 2018. Nano Lett. 18: 5262-5271. PMID: 30047737
- Gastrin-releasing peptide receptor-targeted hybrid peptide/phospholipid pDNA/siRNA delivery systems. | Begum, AA., et al. 2019. Nanomedicine (Lond). 14: 1153-1171. PMID: 31050581
- Peptide-based targeted polymeric nanoparticles for siRNA delivery. | Hussein, WM., et al. 2019. Nanotechnology. 30: 415604. PMID: 31295734
- Condensed desmin and actin cytoskeletal communication in lipid droplets. | Miyasaka, Y., et al. 2019. Cytoskeleton (Hoboken). 76: 477-490. PMID: 31626391
- Delivery of superoxide dismutase to pulmonary epithelium via pH-sensitive liposomes. | Briscoe, P., et al. 1995. Am J Physiol. 268: L374-80. PMID: 7900818
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, 100 mg | sc-202002 | 100 mg | $163.00 | |||
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, 250 mg | sc-202002A | 250 mg | $285.00 | |||
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, 1 g | sc-202002B | 1 g | $749.00 |