1,2-Dioleoyl-sn-glycero-3-phosphocholine (CAS 4235-95-4)

1,2-Dioleoyl-sn-glycero-3-phosphocholine is a phospholipid that is extensively used in the field of biophysics and biochemistry for the study of membrane dynamics and structures. This particular phospholipid is a major component in the creation of liposomes and model cell membranes, which are essential for simulating biological membranes in research. It serves as a mimic of naturally occurring phospholipids, allowing for the examination of membrane fluidity, phase behavior, and protein-lipid interactions. Researchers employ this compound to investigate the delivery systems for various compounds by incorporating it into the liposome bilayer, thus understanding the encapsulation and release mechanisms. Its oleoyl chains are unsaturated, which provides fluidity to the bilayers, making them more similar to natural cell membranes. The study of 1,2-Dioleoyl-sn-glycero-3-phosphocholine also contributes to the understanding of lipid rafts and their role in cellular processes such as signaling and trafficking. It is particularly chosen for its ability to form stable bilayers, which can be used in a variety of experimental conditions, including NMR and X-ray crystallography to decipher structural intricacies.