1,2-Dimyristoyl-sn-glycero-3-phospho-L-serine sodium salt (CAS 105405-50-3)

1,2-Dimyristoyl-sn-glycero-3-phospho-L-serine sodium salt is a synthetic phospholipid commonly used in the study of cellular membrane properties and dynamics, particularly in the context of apoptosis and membrane protein interactions. This molecule features two myristic acid chains attached to the sn-1 and sn-2 positions of a glycerol molecule, with a phosphoserine headgroup at the sn-3 position. The inclusion of the serine headgroup introduces a negative charge, which is pivotal for studying the electrostatic interactions within lipid bilayers and their effects on membrane structure and function. The sodium salt enhances the solubility and usability of this lipid in aqueous environments, facilitating its incorporation into liposomes and model membranes. Researchers utilize this phospholipid to explore the mechanisms of phosphatidylserine exposure on the outer leaflet of the plasma membrane, a key signal in the phagocytic clearance of apoptotic cells. Moreover, 1,2-Dimyristoyl-sn-glycero-3-phospho-L-serine sodium salt serves as a crucial tool for understanding lipid-driven intracellular signaling pathways, contributing to basic research on cellular communication and signaling. These studies are foundational for clarifying the complex roles lipids play in cell biology and biophysics.