Date published: 2026-4-25

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1,2-Dihydroxynaphthalene (CAS 574-00-5)

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Alternate Names:
1,2-Naphthalenediol
CAS Number:
574-00-5
Molecular Weight:
160.17
Molecular Formula:
C10H8O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,2-Dihydroxynaphthalene is a dihydroxylated naphthalene compound that serves as a key intermediate in the synthesis of various dyes and pigments. In organic chemistry research, it is used to explore the mechanisms of aromatic substitution reactions and the synthesis of naphthoquinone derivatives. Its role in the production of dyes is particularly significant in the study of color-fastness and the development of new materials with specific optical properties. In addition to its use in synthetic pathways, 1,2-Dihydroxynaphthalene is also a subject of environmental research, where it is studied for its behavior and transformation products in soil and water systems. Furthermore, researchers use this compound to understand the biodegradation pathways of aromatic hydrocarbons and to develop methods for the remediation of environments contaminated with similar organic compounds.


1,2-Dihydroxynaphthalene (CAS 574-00-5) References

  1. Bacterial metabolism of naphthalene: construction and use of recombinant bacteria to study ring cleavage of 1,2-dihydroxynaphthalene and subsequent reactions.  |  Eaton, RW. and Chapman, PJ. 1992. J Bacteriol. 174: 7542-54. PMID: 1447127
  2. Metabolism of carbaryl via 1,2-dihydroxynaphthalene by soil isolates Pseudomonas sp. strains C4, C5, and C6.  |  Swetha, VP. and Phale, PS. 2005. Appl Environ Microbiol. 71: 5951-6. PMID: 16204509
  3. Formation of depurinating N3adenine and N7guanine adducts after reaction of 1,2-naphthoquinone or enzyme-activated 1,2-dihydroxynaphthalene with DNA. Implications for the mechanism of tumor initiation by naphthalene.  |  Saeed, M., et al. 2007. Chem Biol Interact. 165: 175-88. PMID: 17224140
  4. Purification and characterization of 1-naphthol-2-hydroxylase from carbaryl-degrading Pseudomonas strain c4.  |  Swetha, VP., et al. 2007. J Bacteriol. 189: 2660-6. PMID: 17237179
  5. Metabolism of acenaphthylene via 1,2-dihydroxynaphthalene and catechol by Stenotrophomonas sp. RMSK.  |  Nayak, AS., et al. 2009. Biodegradation. 20: 837-43. PMID: 19543983
  6. 1,2-Dihydroxynaphthalene as biomarker for a naphthalene exposure in humans.  |  Klotz, K., et al. 2011. Int J Hyg Environ Health. 214: 110-4. PMID: 21147027
  7. Selenium effectively inhibits 1,2-dihydroxynaphthalene-induced apoptosis in human lens epithelial cells through activation of PI3-K/Akt pathway.  |  Zhu, X., et al. 2011. Mol Vis. 17: 2019-27. PMID: 21850177
  8. Glyceraldehyde-3-phosphate dehydrogenase as a quinone reductase in the suppression of 1,2-naphthoquinone protein adduct formation.  |  Miura, T., et al. 2011. Free Radic Biol Med. 51: 2082-9. PMID: 21963991
  9. Kinetic and spectroscopic characterization of 1-naphthol 2-hydroxylase from Pseudomonas sp. strain C5.  |  Trivedi, VD., et al. 2014. Appl Biochem Biotechnol. 172: 3964-77. PMID: 24599669
  10. Reliable quantification of 1,2-dihydroxynaphthalene in urine using a conjugated reference compound for calibration.  |  Zobel, M., et al. 2017. Anal Bioanal Chem. 409: 6861-6872. PMID: 29018900
  11. Suitability of several naphthalene metabolites for their application in biomonitoring studies.  |  Klotz, K., et al. 2018. Toxicol Lett. 298: 91-98. PMID: 29990563
  12. Sensitive Simultaneous Determinations of 1,2-Dihydroxynaphthalene and Catechol by an Amperometric Biosensor.  |  Ghozali, AA., et al. 2021. Anal Sci. 37: 991-995. PMID: 33281132
  13. Naphthalene metabolism by pseudomonads: purification and properties of 1,2-dihydroxynaphthalene oxygenase.  |  Patel, TR. and Barnsley, EA. 1980. J Bacteriol. 143: 668-73. PMID: 7204331

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,2-Dihydroxynaphthalene, 250 mg

sc-222835
250 mg
$124.00