Molecular structure of 1,2-Dihydro-2,2,4-trimethylquinoline, CAS Number: 147-47-7
1,2-Dihydro-2,2,4-trimethylquinoline (CAS 147-47-7)
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Alternate Names:
Good-rite 3140; Hydroquin; NSC 4175; Polnox R
CAS Number:
147-47-7
Molecular Weight:
173.25
Molecular Formula:
C12H15N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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1,2-dihydro-2,2,4-trimethylquinoline (2,2,4-Trimethyl-1,2-dihydroquinoline) is a significant heterocyclic aromatic compound utilized as a intermediate in the synthesis of various pharmaceuticals and compounds. It typically appears as a dark cloudy copper-colored or yellow liquid with no distinct odor. This compound has played a role in synthesizing several drugs, including the anti-cancer drug docetaxel and the anti-inflammatory drug celecoxib. Additionally, 1,2-dihydro-2,2,4-trimethylquinoline functions as an antioxidant in styrene-butadiene and nitrile-butadiene rubbers and latexes. Due to its resemblance to quinoline, a known rodent carcinogen, this compound has been selected for evaluation regarding its potential carcinogenic activity.
1,2-Dihydro-2,2,4-trimethylquinoline (CAS 147-47-7) References
- Carcinogenicity of dermally administered 1,2-dihydro-2,2,4-trimethylquinoline monomer in F344 rats and B6C3F1 mice. | Irwin, RD., et al. 1999. J Appl Toxicol. 19: 125-32. PMID: 10215184
- p53 induction as a genotoxic test for twenty-five chemicals undergoing in vivo carcinogenicity testing. | Duerksen-Hughes, PJ., et al. 1999. Environ Health Perspect. 107: 805-12. PMID: 10504146
- Evaluation of the TOPKAT system for predicting the carcinogenicity of chemicals. | Prival, MJ. 2001. Environ Mol Mutagen. 37: 55-69. PMID: 11170242
- NTP Toxicology and Carcinogenesis Studies of 1,2-Dihydro-2,2,4-Trimethylquinoline (CAS No. 147-47-7) in F344/N Rats and B6C3F1 Mice (Dermal Studies) and the Dermal Initiation/Promotion Study in Female Sencar Mice. | ,. 1997. Natl Toxicol Program Tech Rep Ser. 456: 1-312. PMID: 12587020
- Absorption, distribution, metabolism, and excretion of 1,2-dihydro-2,2,4-trimethylquinoline in the male F344 rat. | Ioannou, YM., et al. 1987. Drug Metab Dispos. 15: 367-73. PMID: 2886313
- Overview of intentionally used food contact chemicals and their hazards. | Groh, KJ., et al. 2021. Environ Int. 150: 106225. PMID: 33272655
- The NIEHS Predictive-Toxicology Evaluation Project. | Bristol, DW., et al. 1996. Environ Health Perspect. 104 Suppl 5: 1001-10. PMID: 8933048
- Use of the Syrian hamster embryo cell transformation assay for carcinogenicity prediction of chemicals currently being tested by the National Toxicology Program in rodent bioassays. | Kerckaert, GA., et al. 1996. Environ Health Perspect. 104 Suppl 5: 1075-84. PMID: 8933057
- A mechanism-mediated model for carcinogenicity: model content and prediction of the outcome of rodent carcinogenicity bioassays currently being conducted on 25 organic chemicals. | Purdy, R. 1996. Environ Health Perspect. 104 Suppl 5: 1085-94. PMID: 8933058
- Predictions for the outcome of rodent carcinogenicity bioassays: identification of trans-species carcinogens and noncarcinogens. | Tennant, RW. and Spalding, J. 1996. Environ Health Perspect. 104 Suppl 5: 1095-100. PMID: 8933059
- Prediction of rodent carcinogenicity for 30 chemicals. | Ashby, J. 1996. Environ Health Perspect. 104 Suppl 5: 1101-4. PMID: 8933060
- Study on fluorimetric properties of 1,2-dihydro-2,2,4-trimethylquinoline | Moldovan, Z., Alexandrescu, L., Vasilescu, I., & Radu, L. 2006. Journal of the Iranian Chemical Society. 3: 305-311.
- Synthesis and Crystal Structures of Methyl 3,4,5-Trimethoxybenzoate and 1,2-Dihydro-2,2,4-Trimethylquinoline Derivatives | Fotie, J., Olvera, A., Ayer, S. K., Djieutedjeu, H., & Poudeu, P. F. 2015. Journal of Chemical Crystallography. 45: 1-8.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1,2-Dihydro-2,2,4-trimethylquinoline, 2.5 g | sc-498540 | 2.5 g | $360.00 | |||
1,2-Dihydro-2,2,4-trimethylquinoline, 25 g | sc-498540A | 25 g | $2500.00 |