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1,2-Dihexanoyl-sn-glycerol (CAS 30403-47-5)

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Application:
1,2-Dihexanoyl-sn-glycerol is a diacylglycerol analog
CAS Number:
30403-47-5
Molecular Weight:
288.38
Molecular Formula:
C15H28O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,2-Dihexanoyl-sn-glycerol is a chemical compound that has garnered interest in scientific research due to its potential applications in various fields. Studies have focused on investigating the mechanisms of action and exploring the diverse research applications of this compound. Research has demonstrated that 1,2-Dihexanoyl-sn-glycerol can act as a cell-permeable analog of diacylglycerol (DAG), a key signaling molecule in cellular processes. By mimicking DAG, this compound has been utilized to investigate signaling pathways involving protein kinase C (PKC) activation, calcium mobilization, and lipid metabolism. Researchers have employed 1,2-Dihexanoyl-sn-glycerol to explain the roles of DAG-mediated signaling in cellular functions, including proliferation, differentiation, and apoptosis. Furthermore, this chemical has found applications in lipid research and drug delivery systems. Its unique structure and hydrophobic properties make it useful for studying lipid bilayers, membrane properties, and lipid-protein interactions. Additionally, 1,2-Dihexanoyl-sn-glycerol has been incorporated into liposomal formulations as a vehicle for drug delivery, enabling the controlled release of biological agents and enhancing their bioavailability. 1,2-Dihexanoyl-sn-glycerol has also been investigated in the field of biophysical research, particularly in studies involving surface tension and interfacial properties. Its ability to alter the surface properties of liquids and solids has been utilized in experiments exploring wetting phenomena, emulsions, and self-assembly processes.


1,2-Dihexanoyl-sn-glycerol (CAS 30403-47-5) References

  1. Analysis of a novel diacylglycerol kinase from Dictyostelium discoideum: DGKA.  |  Ostroski, M., et al. 2005. Biochemistry. 44: 10199-207. PMID: 16042397
  2. Analysis of two diacylglycerol kinase activities in mixed micelles.  |  Tu-Sekine, B., et al. 2006. Adv Enzyme Regul. 46: 12-24. PMID: 16854454
  3. Decrease of cellular ATP by dihexanoylglycerol may limit responses to protein kinase C activation.  |  Dawson, J., et al. 1987. FEBS Lett. 214: 171-5. PMID: 3032680
  4. Evidence that a second stereochemical centre in diacylglycerols defines interaction at the recognition site on protein kinase C.  |  Bonser, RW., et al. 1988. FEBS Lett. 234: 341-4. PMID: 3164689
  5. Stereospecific labeling of the glycerol moiety: synthesis of 1,2-dioleoyl-sn-[3-3H]glycero-3-phospho(1-rac-glycerol).  |  Schmitt, JD., et al. 1995. Chem Phys Lipids. 77: 131-7. PMID: 7586097
  6. Characterization of two second messenger pathways and their interactions in eliciting the human sperm acrosome reaction.  |  Doherty, CM., et al. 1995. J Androl. 16: 36-46. PMID: 7768751
  7. Evidence that protein kinase C alpha has reduced affinity towards 1,2-dioctanoyl-sn-glycerol: the effects of lipid activators on phorbol ester binding and kinase activity.  |  MacEwan, DJ., et al. 1993. Eur J Pharmacol. 246: 9-18. PMID: 8354345
  8. Kinetic selectivity of cholinephosphotransferase in mouse liver: the Km for CDP-choline depends on diacylglycerol structure.  |  Mantel, CR., et al. 1993. Biochem J. 289 (Pt 3): 815-20. PMID: 8382052
  9. Activation of phospholipase C and protein kinase C has little involvement in ADP-induced primary aggregation of human platelets: effects of diacylglycerols, the diacylglycerols, the diacylglycerol kinase inhibitor R59022, staurosporine and okadaic acid.  |  Packham, MA., et al. 1993. Biochem J. 290 (Pt 3): 849-56. PMID: 8384448
  10. Effect of diacylglycerols on osteoclastic bone resorption.  |  Moonga, BS., et al. 1996. Calcif Tissue Int. 59: 105-8. PMID: 8687978

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,2-Dihexanoyl-sn-glycerol, 25 mg

sc-220509
25 mg
$108.00

1,2-Dihexanoyl-sn-glycerol, 50 mg

sc-220509A
50 mg
$183.00