1,2-Dihexadecanoyl-rac-glycero-3-phospho-rac-(1-glycerol) ammonium salt (CAS 73548-70-6)

1,2-Dihexadecanoyl-rac-glycero-3-phospho-rac-(1-glycerol) ammonium salt, commonly known as DPPG-NH4, is a synthetic phospholipid of notable interest in the field of biochemical and biophysical research. It belongs to a class of molecules that are pivotal components of cellular membranes, mirroring the structural and functional attributes of naturally occurring phosphoglycerides. The unique amphipathic nature of DPPG-NH4, characterized by its hydrophobic acyl chains and a hydrophilic phosphate glycerol headgroup, allows it to form bilayers and vesicles, crucial for studying membrane dynamics and interactions in model systems. This chemical serves as an integral part of experimental setups investigating the biophysical properties of lipids, including phase behavior, membrane fluidity, and permeability. Additionally, DPPG-NH4 has been extensively utilized in the exploration of lipid-protein interactions, where it mimics the environment of biological membranes to study the embedding and behavior of proteins and peptides within the lipid matrix. Its role is critical in understanding mechanisms of molecular transport and signaling across the membrane barrier without involving the complexities of cellular systems, thereby providing clearer insights into the fundamental processes that govern cellular membrane functionality. Researchers value DPPG-NH4 for its ability to create controlled, reproducible environments that aid in the elucidation of lipid-related mechanisms at the molecular level.