1,2-Dichloropropane (CAS 78-87-5)
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1,2-Dichloropropane is a chlorinated hydrocarbon that has been extensively utilized in the field of organic synthesis and as a solvent in various industrial processes. This chemical serves a pivotal role in the synthesis of other compounds due to its ability to act as an intermediate in the production of epoxides, glycols, and a variety of polymers. Its mechanism of action involves participation in substitution reactions where its chlorine atoms can be replaced by other groups, facilitating the formation of diverse chemical structures. In research applications, 1,2-dichloropropane is often employed in the study of chemical kinetics and mechanisms, especially in reactions that require a stable yet reactive chlorinated compound. Its volatility and reactivity make it a useful solvent and a reagent in organic synthesis labs, where understanding the behavior of chlorinated hydrocarbons under different conditions is essential.
1,2-Dichloropropane (CAS 78-87-5) References
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- Modifying effects of 1,2-dichloropropane on N-nitrosobis(2-oxopropyl)amine-induced cholangiocarcinogenesis in male Syrian hamsters. | Gi, M., et al. 2015. J Toxicol Sci. 40: 647-56. PMID: 26354381
- Relationship between cumulative exposure to 1,2-dichloropropane and incidence risk of cholangiocarcinoma among offset printing workers. | Kumagai, S., et al. 2016. Occup Environ Med. 73: 545-52. PMID: 27371662
- 1,2-Dichloropropane generates phosphorylated histone H2AX via cytochrome P450 2E1-mediated metabolism. | Toyooka, T., et al. 2017. Toxicol Lett. 272: 60-67. PMID: 28300663
- Exposure of Mice to 1,2-Dichloropropane Induces CYP450-Dependent Proliferation and Apoptosis of Cholangiocytes. | Zhang, X., et al. 2018. Toxicol Sci. 162: 559-569. PMID: 29228347
- Acute inhalation co-exposure to 1,2-dichloropropane and dichloromethane cause liver damage by inhibiting mitochondrial respiration and defense ability in mice. | Wang, H., et al. 2019. J Appl Toxicol. 39: 260-270. PMID: 30240022
- Exposure to 1,2-Dichloropropane Upregulates the Expression of Activation-Induced Cytidine Deaminase (AID) in Human Cholangiocytes Co-Cultured With Macrophages. | Zong, C., et al. 2019. Toxicol Sci. 168: 137-148. PMID: 30452740
- Reductive dechlorination of 1,2-dichloroethane in the presence of chloroethenes and 1,2-dichloropropane as co-contaminants. | Peng, P., et al. 2019. Appl Microbiol Biotechnol. 103: 6837-6849. PMID: 31250061
- 1,2-Dichloropropane (1,2-DCP)-Induced Angiogenesis in Dermatitis. | Jin, M., et al. 2019. Toxicol Res. 35: 361-369. PMID: 31636847
- Proteomic analysis of liver proteins of mice exposed to 1,2-dichloropropane. | Zhang, X., et al. 2020. Arch Toxicol. 94: 2691-2705. PMID: 32435916
- 1,2-Dichloropropane induces γ-H2AX expression in human cholangiocytes only in the presence of macrophages. | Takizawa, R., et al. 2021. Toxicol Lett. 349: 134-144. PMID: 34153406
- Role of Macrophages in Cytotoxicity, Reactive Oxygen Species Production and DNA Damage in 1,2-Dichloropropane-Exposed Human Cholangiocytes In Vitro. | Ekuban, A., et al. 2021. Toxics. 9: PMID: 34205922
- Transcriptome analysis of human cholangiocytes exposed to carcinogenic 1,2-dichloropropane in the presence of macrophages in vitro. | Ekuban, A., et al. 2022. Sci Rep. 12: 11222. PMID: 35780190
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1,2-Dichloropropane, 25 g | sc-237677 | 25 g | $204.00 | |||
1,2-Dichloropropane, 500 g | sc-237677A | 500 g | $428.00 |