Date published: 2026-4-26

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1,2-Diaminoanthraquinone (CAS 1758-68-5)

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Alternate Names:
1,2-DAA
Application:
1,2-Diaminoanthraquinone is for the direct detection of nitric oxide
CAS Number:
1758-68-5
Molecular Weight:
238.24
Molecular Formula:
C14H10N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,2-Diaminoanthraquinone is a useful reagent for the direct detection of nitric oxide (NO) DAA is non-fluorescent however, it reacts with NO, in the presence of oxygen, to form DAA triazole, yielding red fluorescence, which is visible with a rhodamine filter (lambda ≥ 580 nm). It is an enzyme substrate shown to inhibit the activity of glutathione reductase. It is also used as a fluorescent probe for analytical chemistry.


1,2-Diaminoanthraquinone (CAS 1758-68-5) References

  1. Fluorescence of 1,2-diaminoanthraquinone and its nitric oxide reaction product within macrophage cells.  |  Marín, MJ., et al. 2011. Chembiochem. 12: 2471-7. PMID: 21953703
  2. Determination of human serum semicarbazide-sensitive amine oxidase activity via flow injection analysis with fluorescence detection after online derivatization of the enzymatically produced benzaldehyde with 1,2-diaminoanthraquinone.  |  El-Maghrabey, MH., et al. 2015. Anal Chim Acta. 881: 139-47. PMID: 26041530
  3. Influence of polymer composition on the sensitivity towards nitrite and nitric oxide of colorimetric disposable test strips.  |  Fabregat, V., et al. 2017. Environ Sci Pollut Res Int. 24: 3448-3455. PMID: 27873112
  4. Synthesis of novel sugar or azasugar modified anthra[1,2-d] imidazole-6,11-dione derivatives and biological evaluation.  |  Wang, Q., et al. 2018. Carbohydr Res. 460: 29-33. PMID: 29501861
  5. Nitric oxide detection methods in vitro and in vivo.  |  Goshi, E., et al. 2019. Med Gas Res. 9: 192-207. PMID: 31898604
  6. Rationally designed imidazole derivative as colorimetric and fluorometric sensor for selective, qualitative and quantitative cyanide ion detection in real time samples.  |  Bhaskar, R., et al. 2020. Spectrochim Acta A Mol Biomol Spectrosc. 234: 118212. PMID: 32224435
  7. An anthraquinone-based highly selective colorimetric and fluorometric sensor for sequential detection of Cu2+ and S2- with intracellular application.  |  Hou, L., et al. 2017. J Mater Chem B. 5: 8957-8966. PMID: 32264122
  8. DNA-Binding Capabilities and Anticancer Activities of Ruthenium(II) Cymene Complexes with (Poly)cyclic Aromatic Diamine Ligands.  |  Alsaeedi, MS., et al. 2020. Molecules. 26: PMID: 33375289
  9. Phenothiazine, anthraquinone and related tricyclic derivatives as inhibitors of monoamine oxidase.  |  Lefin, R., et al. 2022. Bioorg Med Chem. 54: 116558. PMID: 34915314
  10. Mono and dual hetero-structured M@poly-1,2 diaminoanthraquinone (M = Pt, Pd and Pt-Pd) catalysts for the electrooxidation of small organic fuels in alkaline medium.  |  Hathoot, AA., et al. 2019. RSC Adv. 9: 1849-1858. PMID: 35516099
  11. Planar and Helical Dinaphthophenazines.  |  Chen, F., et al. 2022. J Org Chem. 87: 7635-7642. PMID: 35616330
  12. Evaluation of Green-Synthesized Cuprospinel Nanoparticles as a Nanosensor for Detection of Low-Concentration Cd(II) Ion in the Aqueous Solutions by the Quartz Crystal Microbalance Method.  |  Al-Qasmi, N., et al. 2022. Materials (Basel). 15: PMID: 36143550
  13. Discovery of New Microbial Collagenase Inhibitors.  |  Nitulescu, G., et al. 2022. Life (Basel). 12: PMID: 36556479

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,2-Diaminoanthraquinone, 25 g

sc-359839
25 g
$105.00