Molecular structure of 1,2-bis(Heptanoylthio)glycerophosphocholine, CAS Number: 89019-63-6
1,2-bis(Heptanoylthio)glycerophosphocholine (CAS 89019-63-6)
Alternate Names:
(S)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxoheptyl)thio]-3,5-dioxa-9-thia-4-phosphahexadecan-1-aminium
Application:
1,2-bis(Heptanoylthio)glycerophosphocholine is a lipid tool for assay of PLA2 activity
CAS Number:
89019-63-6
Purity:
≥95%
Molecular Weight:
513.7
Molecular Formula:
C22H44NO6PS2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
1,2-bis(Heptanoylthio)glycerophosphocholine is a synthetic thiol phosphoglyceride derived from D-mannitol which functions as a substrate for phospholipase A2 (PLA2). Hydrolysis of 1,2-bis(Heptanoylthio)glycerophosphocholine by PLA2 produces free thiols, which may be derivitized with dithionitrobenzoic acid to form the chromophore for a spectrophotometric assay of intracellular and membrane-bound PLA2 activity. Release of Arachidonic Acid (sc-200770) from membrane phospholipids mediated by PLA2 is thought to regulate eicosanoid production and marked PLA2 activity is observed in correlation with inflammation states. Inhibitors of PLA2 activity, presenting potential intervention upon the inflammatory role of PLA2, have been identified using this assay design.
1,2-bis(Heptanoylthio)glycerophosphocholine (CAS 89019-63-6) References
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Substrate of:
PLA1, and PLA2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1,2-bis(Heptanoylthio)glycerophosphocholine, 5 mg | sc-201428 | 5 mg | $296.00 |