Date published: 2025-10-15

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1,2-benzoxazol-3-ylmethanesulfonamide (CAS 68291-97-4)

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Alternate Names:
Zonisamide
Application:
1,2-benzoxazol-3-ylmethanesulfonamide is an anticonvulsant blocker of voltage-sensitive T-type Ca2+ and Na+ channels
CAS Number:
68291-97-4
Molecular Weight:
212.23
Molecular Formula:
C8H8N2O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,2-Benzoxazol-3-ylmethanesulfonamide is a compound that captures the interest of researchers due to its inclusion of a benzoxazole ring, a structure found in various biologically active molecules. In the field of organic chemistry, this compound is particularly valuable for its potential as a chemical intermediate in the synthesis of more complex molecules that include benzoxazole derivatives. The methanesulfonamide moiety presents an opportunity for sulfonamide bond formation, which is a key step in constructing certain heterocyclic compounds that are studied for their electronic and photophysical properties. This makes it an important subject in the development of organic light-emitting diodes (OLEDs) and other electronic materials. Additionally, 1,2-Benzoxazol-3-ylmethanesulfonamide is utilized in the study of molecular recognition processes, where its unique structural features may influence binding interactions with various biological targets.


1,2-benzoxazol-3-ylmethanesulfonamide (CAS 68291-97-4) References

  1. Zonisamide: chemistry, mechanism of action, and pharmacokinetics.  |  Leppik, IE. 2004. Seizure. 13 Suppl 1: S5-9; discussion S10. PMID: 15511691
  2. Drug monitoring and toxicology: a procedure for the monitoring of levetiracetam and zonisamide by HPLC-UV.  |  Juenke, J., et al. 2006. J Anal Toxicol. 30: 27-30. PMID: 16620528
  3. Simultaneous determination of lamotrigine, zonisamide, and carbamazepine in human plasma by high-performance liquid chromatography.  |  Greiner-Sosanko, E., et al. 2007. Biomed Chromatogr. 21: 225-8. PMID: 17230449
  4. Effects of zonisamide on experimental tremors in rats.  |  Miwa, H., et al. 2008. Parkinsonism Relat Disord. 14: 33-6. PMID: 17587636
  5. Disposition and safety of zonisamide after intravenous and oral single dose and oral multiple dosing in normal hound dogs.  |  Boothe, DM. and Perkins, J. 2008. J Vet Pharmacol Ther. 31: 544-53. PMID: 19000278
  6. Zonisamide increases dopamine turnover in the striatum of mice and common marmosets treated with MPTP.  |  Yabe, H., et al. 2009. J Pharmacol Sci. 110: 64-8. PMID: 19403994
  7. The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance.  |  Sonsalla, PK., et al. 2010. Exp Neurol. 221: 329-34. PMID: 19948168
  8. Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD.  |  Kawajiri, S., et al. 2010. Neurosci Lett. 481: 88-91. PMID: 20600601
  9. Post-treatment with voltage-gated Na(+) channel blocker attenuates kainic acid-induced apoptosis in rat primary hippocampal neurons.  |  Das, A., et al. 2010. Neurochem Res. 35: 2175-83. PMID: 21127971
  10. Zonisamide ameliorates levodopa-induced dyskinesia and reduces expression of striatal genes in Parkinson model rats.  |  Oki, M., et al. 2017. Neurosci Res. 122: 45-50. PMID: 28577977
  11. Zonisamide, an antiepileptic drug, alleviates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress.  |  Tian, JH., et al. 2021. Acta Pharmacol Sin. 42: 393-403. PMID: 32647341
  12. Zonisamide alleviates cardiac hypertrophy in rats by increasing Hrd1 expression and inhibiting endoplasmic reticulum stress.  |  Wu, Q., et al. 2021. Acta Pharmacol Sin. 42: 1587-1597. PMID: 33495518
  13. Presumed zonisamide-induced blood dyscrasias in four dogs.  |  Brandifino, M., et al. 2022. J Vet Emerg Crit Care (San Antonio). 32: 805-811. PMID: 35739607

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,2-benzoxazol-3-ylmethanesulfonamide, 250 mg

sc-339184
250 mg
$162.00

1,2-benzoxazol-3-ylmethanesulfonamide, 1 g

sc-339184A
1 g
$331.00