Date published: 2026-5-30

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1,2,3,4-Tetrahydroharmane-3-carboxylic acid (CAS 5470-37-1)

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Alternate Names:
1-Methyl-1,2,3,4-Tetrahydropyrido[3,4-b]indole-3-carboxylic acid; 1-Methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid; NSC 26225
CAS Number:
5470-37-1
Molecular Weight:
230.26
Molecular Formula:
C13H14N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,2,3,4-Tetrahydroharmane-3-carboxylic acid, a polycyclic aromatic compound, exhibits notable antioxidant properties. It is also shown to inhibit protein synthesis and production of growth factors within cells. This compound′s inhibition of acid formation is done by its role as a buffer against protons. 1,2,3,4-Tetrahydroharmane-3-carboxylic acid can also cross cell membranes through passive diffusion, highlighting its cellular permeability. Implicated in eosinophilia-myalgia syndrome associated with L-tryptophan ingestion.


1,2,3,4-Tetrahydroharmane-3-carboxylic acid (CAS 5470-37-1) References

  1. Lactobacillus casei expressing methylglyoxal synthase causes browning and heterocyclic amine formation in Parmesan cheese extract.  |  Gandhi, NN., et al. 2019. J Dairy Sci. 102: 100-112. PMID: 30415846
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  5. Liquid Chromatography-Mass Spectrometry-Based Metabolomics for Understanding the Compositional Changes Induced by Oxidative or Anoxic Storage of Red Wines.  |  Ontañón, I., et al. 2020. J Agric Food Chem. 68: 13367-13379. PMID: 33063507
  6. Tuning gut microbiota through a probiotic blend in gemcitabine-treated pancreatic cancer xenografted mice.  |  Panebianco, C., et al. 2021. Clin Transl Med. 11: e580. PMID: 34841697
  7. In vitro antioxidant activities of five β-carboline alkaloids, molecular docking, and dynamic simulations  |  Senhaji, S., Lamchouri, F., Akabli, T., & Toufik, H. 2022. Structural Chemistry. 33(3): 883-895.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,2,3,4-Tetrahydroharmane-3-carboxylic acid, 100 mg

sc-251565
100 mg
$81.00