1,2,3,4-Tetra-O-benzoyl-D-glucuronic Acid

1,2,3,4-Tetra-O-benzoyl-D-glucuronic acid is a fully benzoylated derivative of glucuronic acid, known for its utility as a protected glycosyl donor in carbohydrate synthesis. The benzoyl groups at the hydroxyl positions (1, 2, 3, and 4) stabilize the molecule and make it a versatile building block for glycosylation reactions. This compound is particularly useful in glycoscience for synthesizing complex glycosides, providing control over regioselectivity and stereoselectivity during the formation of glycosidic bonds. Researchers leverage 1,2,3,4-Tetra-O-benzoyl-D-glucuronic acid to study the structure and function of glycoconjugates like glycosaminoglycans, glycolipids, and glycoproteins, which feature glucuronic acid residues. It′s particularly valuable in constructing oligosaccharides and carbohydrate-based probes that help explain glycosyltransferase specificity and enzyme mechanisms involved in glycan modification. These synthetic glycoconjugates and glycans are also employed in studying carbohydrate-binding proteins and antibodies that interact with glucuronic acid-containing structures. Furthermore, the protected glucuronic acid derivative is used in generating inhibitors for glycosidases and glycosyltransferases. It is instrumental in revealing the role of glucuronic acid-containing glycoconjugates in various biological pathways, aiding the development of high-throughput assays to screen carbohydrate-active enzymes.