1,2,3,4-Tetra-O-acetyl-β-D-glucuronic Acid (CAS 62133-77-1)

1,2,3,4-Tetra-O-acetyl-β-D-glucuronic acid (TGA) emerges as a naturally occurring sugar acid that finds its presence in various plants and animals. As a structural isomer of glucuronic acid, 1,2,3,4-Tetra-O-acetyl-β-D-glucuronic acid plays a pivotal role as a constituent of the glycosaminoglycan (GAG) family of polysaccharides. Within the intricate landscape of biological processes, 1,2,3,4-Tetra-O-acetyl-β-D-glucuronic acid assumes significance as a ubiquitous component of the extracellular matrix, contributing to activities such as cell adhesion, cell proliferation, and cell migration. Its involvement extends to the synthesis of heparin, a glycosaminoglycan essential for blood clotting and wound healing. In its versatile interactions, 1,2,3,4-Tetra-O-acetyl-β-D-glucuronic acid has been observed to engage with a diverse array of proteins, including integrinstransmembrane receptors intimately linked with cell adhesion. Through its binding with integrins, 1,2,3,4-Tetra-O-acetyl-β-D-glucuronic acid facilitates their clustering and activation, thereby enabling the formation of adhesions between cells and the extracellular matrix. Furthermore, this compound exhibits interactions with other proteins like laminin and fibronectin, both integral to the construction and upkeep of the extracellular matrix. In summary, 1,2,3,4-Tetra-O-acetyl-β-D-glucuronic acid holds a prominent role in biological systems, intricately participating in vital cellular processes and influencing the dynamic interplay of the extracellular environment.