Date published: 2026-4-27

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1,2,3,4-Butanetetracarboxylic acid (CAS 1703-58-8)

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Alternate Names:
Butane-1,2,3,4-tetracarboxylic acid
CAS Number:
1703-58-8
Molecular Weight:
234.16
Molecular Formula:
C8H10O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,2,3,4-Butanetetracarboxylic acid (BTCA), a dicarboxylic acid containing four carbon atoms, serves as a valuable component in numerous scientific research applications. In organic and inorganic chemistry, it serves as a reactant for synthesizing diverse compounds. In biochemistry, it acts as a substrate for the synthesis of proteins and enzymes. Furthermore, 1,2,3,4-Butanetetracarboxylic acid contributes to the study of cell metabolism, as it can be utilized to measure cellular respiration rates. The complete mechanism of action of 1,2,3,4-Butanetetracarboxylic acid remains incompletely understood. However, it is believed to function as an inhibitor of the enzyme aconitase, which plays a role in carbohydrate metabolism.


1,2,3,4-Butanetetracarboxylic acid (CAS 1703-58-8) References

  1. Developmental toxicity evaluation of 1,2,3,4-butanetetracarboxylic acid in Sprague Dawley (CD) rats.  |  George, JD., et al. 2001. Reprod Toxicol. 15: 413-20. PMID: 11489597
  2. Unusual (mu-aqua)bis(mu-carboxylate) bridge in homometallic M(II) (M=Mn, Co and Ni) two-dimensional compounds based on the 1,2,3,4-butanetetracarboxylic acid: synthesis, structure, and magnetic properties.  |  Cañadillas-Delgado, L., et al. 2007. Inorg Chem. 46: 7458-65. PMID: 17691768
  3. Catalytic actions of alkaline salts in reactions between 1,2,3,4-butanetetracarboxylic acid and cellulose: II. Esterification.  |  Ji, B., et al. 2015. Carbohydr Polym. 132: 228-36. PMID: 26256345
  4. Effects of divalent anionic catalysts on cross-linking of cellulose with 1,2,3,4-butanetetracarboxylic acid.  |  Ji, B., et al. 2018. Carbohydr Polym. 181: 292-299. PMID: 29253975
  5. Catalytic and ionic cross-linking actions of l-glutamate salt for the modification of cellulose by 1,2,3,4-butanetetracarboxylic acid.  |  Ji, B., et al. 2019. Carbohydr Polym. 207: 288-296. PMID: 30600011
  6. Immobilized lysozyme onto 1,2,3,4-butanetetracarboxylic (BTCA)-modified magnetic cellulose microsphere for improving bio-catalytic stability and activities.  |  Xue, F., et al. 2019. Enzyme Microb Technol. 131: 109425. PMID: 31615685
  7. Adsorption of Pb(II) ions from contaminated water by 1,2,3,4-butanetetracarboxylic acid-modified microcrystalline cellulose: Isotherms, kinetics, and thermodynamic studies.  |  Hashem, A., et al. 2020. Int J Biol Macromol. 164: 3193-3203. PMID: 32853617
  8. Locating the Reaction Site of 1,2,3,4-Butanetetracarboxylic Acid Carboxyl and Cellulose Hydroxyl in the Esterification Cross-Linking.  |  Ji, B., et al. 2021. ACS Omega. 6: 28394-28402. PMID: 34723036
  9. The effect of crosslinking on ion transport in nanocellulose-based membranes.  |  Yang, H., et al. 2022. Carbohydr Polym. 278: 118938. PMID: 34973756
  10. Adsorption of Cationic Contaminants by Cyclodextrin Nanosponges Cross-Linked with 1,2,3,4-Butanetetracarboxylic Acid and Poly(vinyl alcohol).  |  Martwong, E., et al. 2022. Polymers (Basel). 14: PMID: 35054747
  11. Multivariate optimization applied to the synthesis and reuse of a new sugarcane bagasse-based biosorbent to remove Cd(II) and Pb(II) from aqueous solutions.  |  Elias, MMC., et al. 2022. Environ Sci Pollut Res Int. 29: 79954-79976. PMID: 35190982
  12. Spin-Induced Organization of Cellulose Nanocrystals.  |  Al-Bustami, H., et al. 2022. Biomacromolecules. 23: 2098-2105. PMID: 35289591
  13. Bio-synthesis of itaconic acid as an anti-crease finish for cellulosic fiber fabric.  |  Boondaeng, A., et al. 2021. RSC Adv. 11: 25943-25950. PMID: 35479465
  14. Cotton Cord Coated with Cyclodextrin Polymers for Paraquat Removal from Water.  |  Martwong, E., et al. 2022. Polymers (Basel). 14: PMID: 35683872
  15. Novel Strategy to fabricate Antiwrinkle Cotton fabrics with 1,2,3,4-Butanetetracarboxylic Acid under a Low Temperature.  |  Hu, H., et al. 2022. ACS Omega. 7: 30093-30103. PMID: 36061653

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,2,3,4-Butanetetracarboxylic acid, 100 g

sc-251564
100 g
$64.00

1,2,3,4-Butanetetracarboxylic acid, 500 g

sc-251564A
500 g
$162.00