1,2,3,4,6-Penta-O-galloyl-β-D-glucopyranose (CAS 14937-32-7)
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1,2,3,4,6-Penta-O-galloyl-β-D-glucopyranose (PGG) is a polyphenol found in various plants that is known for its antioxidant and anti-inflammatory properties. It is a type of gallotannin that is found in the bark of trees such as oak and chestnut, as well as in some fruits and vegetables. It induces apoptosis in DU145 and LNCaP cells, affects downstream products of (FRAP) mTOR, and is an inhibitor of PAI-1. 1,2,3,4,6-Penta-O-galloyl-β-D-glucopyranose exhibits an in vitro growth-inhibiting effect on human hepatocellular carcinoma cell line, SK-HEP-1 cells. It has also been shown to increase the activity of certain enzymes, such as superoxide dismutase and catalase, which are important for protecting cells from oxidative damage.
1,2,3,4,6-Penta-O-galloyl-β-D-glucopyranose (CAS 14937-32-7) References
- In vitro anti-proliferative effect of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose on human hepatocellular carcinoma cell line, SK-HEP-1 cells. | Oh, GS., et al. 2001. Cancer Lett. 174: 17-24. PMID: 11675148
- Alleviation of transient global ischemia/reperfusion-induced brain injury in rats with 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose isolated from Mangifera indica. | Viswanatha, GL., et al. 2013. Eur J Pharmacol. 720: 286-93. PMID: 24157980
- 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose increases a population of T regulatory cells and inhibits IgE production in ovalbumin-sensitized mice. | Kim, YH., et al. 2015. Int Immunopharmacol. 26: 30-6. PMID: 25737197
- 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose Binds to the N-terminal Metal Binding Region to Inhibit Amyloid β-protein Oligomer and Fibril Formation. | de Almeida, NEC., et al. 2017. Int J Mass Spectrom. 420: 24-34. PMID: 29056865
- Natural product 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase. | Li, W., et al. 2022. Acta Pharmacol Sin. 43: 470-482. PMID: 33850276
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1,2,3,4,6-Penta-O-galloyl-β-D-glucopyranose, 10 mg | sc-220537 | 10 mg | $298.00 |