Molecular structure of 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE, CAS Number: 1837-91-8
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE (CAS 1837-91-8)
Alternate Names:
JAK2 Inhibitor II
Application:
1,2,3,4,5,6-Hexabromocyclohexane is a potent and specific inhibitor of JAK2 autophosphorylation
CAS Number:
1837-91-8
Purity:
>97%
Molecular Weight:
557.5
Molecular Formula:
C6H6Br6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1,2,3,4,5,6-Hexabromocyclohexane is a potent and specific inhibitor of JAK2 autophosphorylation. In silico simulation indicates that 1,2,3,4,5,6-Hexabromocyclohexane accesses a binding pocket positioned adjacent to the activation loop on the JAK2 protein. Growth hormone-mediated JAK2 autophosphorylation was greatly reduced by 1,2,3,4,5,6-Hexabromocyclohexane, and it was shown to not block autophosphorylation of the epidermal growth factor receptor.
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE (CAS 1837-91-8) References
- Identification of 1,2,3,4,5,6-hexabromocyclohexane as a small molecule inhibitor of jak2 tyrosine kinase autophosphorylation [correction of autophophorylation]. | Sandberg, EM., et al. 2005. J Med Chem. 48: 2526-33. PMID: 15801842
- Growth hormone-stimulated insulin-like growth factor-1 expression in rainbow trout (Oncorhynchus mykiss) hepatocytes is mediated by ERK, PI3K-AKT, and JAK-STAT. | Reindl, KM., et al. 2011. Am J Physiol Regul Integr Comp Physiol. 301: R236-43. PMID: 21490369
Inhibitor of:
JAK2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE, 25 mg | sc-202398 | 25 mg | $105.00 |