Date published: 2026-4-4

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1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide (CAS 100068-60-8)

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Alternate Names:
DiR iodide; 3H-Indolium, 2-[7-(1,3-dihydro-3,3-dimethyl-1-octadecyl-2H-indol-2-ylidene)-1,3,5-heptatrienyl]-3,3-dimethyl-1-octadecyl-, iodide
CAS Number:
100068-60-8
Molecular Weight:
1013.39
Molecular Formula:
C63H101IN2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide is used to dye membranes but will also dye other hydrophobic structures. It is a environment-sensitive dye that is weakly fluorescent in water. 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide exhibits dark red fluorescence.


1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide (CAS 100068-60-8) References

  1. Use of lipophilic near-infrared dye in whole-body optical imaging of hematopoietic cell homing.  |  Kalchenko, V., et al. 2006. J Biomed Opt. 11: 050507. PMID: 17092148
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  3. In vivo Near-infrared Fluorescence Tumor Imaging Using DiR-loaded Nanocarriers.  |  Liu, H. and Wu, D. 2016. Curr Drug Deliv. 13: 40-8. PMID: 26138681
  4. Cationic PLGA/Eudragit RL nanoparticles for increasing retention time in synovial cavity after intra-articular injection in knee joint.  |  Kim, SR., et al. 2015. Int J Nanomedicine. 10: 5263-71. PMID: 26345227
  5. Gut-derived lymphocyte recruitment to liver and induce liver injury in non-alcoholic fatty liver disease mouse model.  |  Hu, Y., et al. 2016. J Gastroenterol Hepatol. 31: 676-84. PMID: 26430807
  6. Paclitaxel-Paclitaxel Prodrug Nanoassembly as a Versatile Nanoplatform for Combinational Cancer Therapy.  |  Han, X., et al. 2016. ACS Appl Mater Interfaces. 8: 33506-33513. PMID: 27960378
  7. Near-Infrared Cyanine-Loaded Liposome-like Nanocapsules of Camptothecin-Floxuridine Conjugate for Enhanced Chemophotothermal Combination Cancer Therapy.  |  Gao, C., et al. 2018. ACS Appl Mater Interfaces. 10: 3219-3228. PMID: 29299917
  8. Nanostructuring Lipophilic Dyes in Water Using Stable Vesicles, Quatsomes, as Scaffolds and Their Use as Probes for Bioimaging.  |  Ardizzone, A., et al. 2018. Small. 14: e1703851. PMID: 29573545
  9. Self-Assembly of a Pure Photosensitizer as a Versatile Theragnostic Nanoplatform for Imaging-Guided Antitumor Photothermal Therapy.  |  Zhang, X., et al. 2018. ACS Appl Mater Interfaces. 10: 30155-30162. PMID: 30125081
  10. Deep Tumor-Penetrated Nanocages Improve Accessibility to Cancer Stem Cells for Photothermal-Chemotherapy of Breast Cancer Metastasis.  |  Tan, T., et al. 2018. Adv Sci (Weinh). 5: 1801012. PMID: 30581704
  11. Acid-induced degradation of widely used NIR dye DiR causes hypsochromic shift in fluorescence properties.  |  Riehl, M., et al. 2019. Eur J Pharm Sci. 132: 27-33. PMID: 30797028
  12. Lipid-coated CaCO3-PDA nanoparticles as a versatile nanocarrier to enable pH-responsive dual modal imaging-guided combination cancer therapy.  |  Ma, X., et al. 2022. J Mater Chem B. 10: 4096-4104. PMID: 35521641
  13. Exosomes Derived From Kartogenin-Preconditioned Mesenchymal Stem Cells Promote Cartilage Formation and Collagen Maturation for Enthesis Regeneration in a Rat Model of Chronic Rotator Cuff Tear.  |  Cai, J., et al. 2023. Am J Sports Med. 51: 1267-1276. PMID: 36917828

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide, 25 mg

sc-391091
25 mg
$124.00