Date published: 2026-5-19

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1,1-Difluoroacetone (CAS 431-05-0)

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CAS Number:
431-05-0
Molecular Weight:
94.06
Molecular Formula:
C3H4F2O
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,1-Difluoroacetone, a fluorinated analogue of acetone, plays a significant role in organic synthesis and materials science research due to its unique electronic and steric properties. The presence of two fluorine atoms adjacent to the carbonyl group profoundly influences its reactivity, making it an intriguing candidate for various chemical transformations. Its mechanism of action includes serving as a building block for the synthesis of more complex fluorinated compounds, which are of great interest in the development of materials with enhanced chemical resistance, thermal stability, and unique optical properties. The incorporation of 1,1-difluoroacetone into polymers and other macromolecular structures has been explored for creating materials with specific functionalities, such as low refractive indices and high hydrophobicity. Additionally, its role in research extends to the synthesis of fluorinated analogues of bioactive molecules, where it contributes to the understanding of molecular interactions and the exploration of new pathways for chemical synthesis.


1,1-Difluoroacetone (CAS 431-05-0) References

  1. Subtle Structural Differences Trigger Inhibitory Activity of Propafenone Analogues at the Two Polyspecific ABC Transporters: P-Glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP).  |  Schwarz, T., et al. 2016. ChemMedChem. 11: 1380-94. PMID: 26970257
  2. A Scalable Synthesis of the Difluoromethyl-allo-threonyl Hydroxamate-Based LpxC Inhibitor LPC-058.  |  Liang, X., et al. 2016. J Org Chem. 81: 4393-8. PMID: 27128325

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,1-Difluoroacetone, 1 g

sc-297884
1 g
$117.00

1,1-Difluoroacetone, 5 g

sc-297884A
5 g
$356.00