Date published: 2026-4-25

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1,1,1-Tris(hydroxymethyl)propane (CAS 77-99-6)

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Alternate Names:
Trimethylolpropane
CAS Number:
77-99-6
Molecular Weight:
134.17
Molecular Formula:
C6H14O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,1,1-Tris(hydroxymethyl)propane is a compound that functions as a crosslinking agent in the synthesis of polymers and resins. It acts by forming covalent bonds between polymer chains, thereby increasing the strength and stability of the resulting material. 1,1,1-Tris(hydroxymethyl)propane′s mode of action involves reacting with functional groups on the polymer molecules, leading to the formation of a three-dimensional network that enhances the mechanical properties of the material. 1,1,1-Tris(hydroxymethyl)propane can act as a building block in the production of specialty chemicals and intermediates. Its functional role in this involves serving as a precursor for the synthesis of various compounds with specific chemical functionalities. 1,1,1-Tris(hydroxymethyl)propane′s mode of action revolves around its ability to participate in chemical reactions that lead to the formation of crosslinked polymers and the production of diverse chemical products.


1,1,1-Tris(hydroxymethyl)propane (CAS 77-99-6) References

  1. Triol-promoted activation of C-F bonds: Amination of benzylic fluorides under highly concentrated conditions mediated by 1,1,1-tris(hydroxymethyl)propane.  |  Champagne, PA., et al. 2013. Beilstein J Org Chem. 9: 2451-6. PMID: 24367412
  2. The MORPHEUS II protein crystallization screen.  |  Gorrec, F. 2015. Acta Crystallogr F Struct Biol Commun. 71: 831-7. PMID: 26144227
  3. Crystal structures of two mononuclear complexes of terbium(III) nitrate with the tripodal alcohol 1,1,1-tris-(hy-droxy-meth-yl)propane.  |  Gregório, T., et al. 2017. Acta Crystallogr E Crystallogr Commun. 73: 278-285. PMID: 28217359
  4. Modified Hyperbranched Polyglycerol as Dispersant for Size Control and Stabilization of Gold Nanoparticles in Hydrocarbons.  |  Shen, Y., et al. 2017. Nanoscale Res Lett. 12: 525. PMID: 28875345
  5. Direct Single- and Double-Side Triol-Functionalization of the Mixed Type Anderson Polyoxotungstate [Cr(OH)3W6O21]6.  |  Gumerova, NI., et al. 2019. Inorg Chem. 58: 106-113. PMID: 30543282
  6. Poly-(3-ethyl-3-hydroxymethyl)oxetanes-Synthesis and Adhesive Interactions with Polar Substrates.  |  Parzuchowski, P. and Mamiński, MŁ. 2020. Polymers (Basel). 12: PMID: 31963171
  7. Double-Crosslinked Polyurethane Acrylate for Highly Conductive and Stable Polymer Electrolyte.  |  Kim, HN., et al. 2020. Polymers (Basel). 12: PMID: 33142743
  8. High Efficiency and Low Migration Hyperbranched Silicone Contain Macrophotoinitiators for UV-Cured Transparent Coatings.  |  Fan, Y., et al. 2020. Polymers (Basel). 12: PMID: 33339280
  9. Star-Shaped Poly(furfuryl glycidyl ether)-Block-Poly(glyceryl glycerol ether) as an Efficient Agent for the Enhancement of Nifuratel Solubility and for the Formation of Injectable and Self-Healable Hydrogel Platforms for the Gynaecological Therapies.  |  Ziemczonek, P., et al. 2021. Int J Mol Sci. 22: PMID: 34445090
  10. Polyglycerols as Multi-Functional Platforms: Synthesis and Biomedical Applications.  |  Pouyan, P., et al. 2022. Polymers (Basel). 14: PMID: 35808728
  11. Self-Healable, Injectable Hydrogel with Enhanced Clotrimazole Solubilization as a Potential Therapeutic Platform for Gynecology.  |  Gosecka, M., et al. 2022. Biomacromolecules. 23: 4203-4219. PMID: 36073031
  12. Hydrotropic Hydrogels Prepared from Polyglycerol Dendrimers: Enhanced Solubilization and Release of Paclitaxel.  |  Ooya, T. and Lee, J. 2022. Gels. 8: PMID: 36286115
  13. Controlled Synthesis of Dendrite-like Polyglycerols Using Aluminum Complex for Biomedical Applications.  |  Perumal, G., et al. 2023. ACS Omega. 8: 2377-2388. PMID: 36687077

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,1,1-Tris(hydroxymethyl)propane, 25 g

sc-237640A
25 g
$20.00

1,1,1-Tris(hydroxymethyl)propane, 500 g

sc-237640
500 g
$23.00