Date published: 2026-5-5

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1,1,1-Trifluorooctan-2-ol (CAS 453-43-0)

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Alternate Names:
2-Octanol, 1,1,1-trifluoro-; 1-(Trifluoromethyl)heptan-1-ol
CAS Number:
453-43-0
Molecular Weight:
184.20
Molecular Formula:
C8H15F3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,1,1-Trifluorooctan-2-ol, also known as 1,1,1-Trifluoro-2-octanol, is fluorinated alcohol compound holds immense value in the realm of organic chemistry and has exhibited compelling outcomes in diverse scientific research endeavors. Researchers have extensively employed 1,1,1-Trifluorooctan-2-ol in their studies, capitalizing on its distinctive characteristics. The compound′s utility spans a broad range of scientific research studies. It has found extensive use in the synthesis of various organic compounds, including fluorinated aldehydes, ketones, and esters, augmenting the repertoire of available synthetic tools. Furthermore, 1,1,1-Trifluorooctan-2-ol has served as a solvent in numerous chemical reactions, facilitating efficient progress in the laboratory setting. Notably, it has also been harnessed as a chiral auxiliary in asymmetric synthesis reactions, enabling the synthesis of enantiopure compounds with enhanced stereochemical control. Despite its widespread application, the precise mechanism of action of 1,1,1-Trifluorooctan-2-ol remains elusive. However, current understanding suggests that this compound operates as a Lewis acid, effectively coordinating with various nucleophiles. Such coordination events foster the formation of stable intermediates that can undergo subsequent reactions, paving the way for intricate chemical transformations.


1,1,1-Trifluorooctan-2-ol (CAS 453-43-0) References

  1. Difluorooxymethylene-Bridged Liquid Crystals: A Novel Synthesis Based on the Oxidative Alkoxydifluorodesulfuration of Dithianylium Salts.  |  Kirsch, P., et al. 2001. Angew Chem Int Ed Engl. 40: 1480-1484. PMID: 29712355
  2. Ultrashort helix pitch antiferroelectric liquid crystals based on chiral esters of terphenyldicarboxylic acid†  |  E. P. Pozhidaev,ab V. V. Vashchenko,ac V. V. Mikhailenko,c A. I. Krivoshey,c V. A. Barbashov,b L. Shi,a A. K. Srivastava,*a V. G. Chigrinov a and H. S. Kwoka . 2016. J. Mater. Chem. C,. 4: 10339-10346.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,1,1-Trifluorooctan-2-ol, 25 g

sc-258864
25 g
$221.00

1,1,1-Trifluorooctan-2-ol, 100 g

sc-258864A
100 g
$630.00