TSH Antibody (TSH-116): sc-57486

TSH Antibody (TSH-116) is a mouse monoclonal IgG2a antibody that detects TSH protein of human origin by enzyme-linked immunosorbent assay (ELISA). Anti-TSH antibody (TSH-116) is available as the non-conjugated format, providing a reliable tool for researchers studying thyroid function. Thyroid-stimulating hormone (TSH), also known as thyrotropin, is a crucial glycoprotein that plays a significant role in regulating thyroid structure and metabolism by stimulating the release of thyroid hormones. TSH protein is composed of a common α chain and a unique β chain, forming a heterodimer essential for biological activity. Notably, TSHβ is intricately regulated by thyroid hormones, particularly triiodothyronine (T3), as well as various retinoid compounds, ensuring a finely tuned response to the body′s metabolic needs. The interaction of TSH with thyroid-stimulating hormone receptor (TSHR) is vital for maintaining thyroid function, and TSHR exists in multiple glycosylation states, which can influence activity and signaling pathways. The third cytoplasmic loop of TSHR has been identified as critical for regulating inositol phosphate and cyclic adenosine monophosphate (cAMP) formation, highlighting TSH importance in cellular signaling and metabolic regulation.

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TSH Antibody (TSH-116) References:

1. Substitutions of different regions of the third cytoplasmic loop of the thyrotropin (TSH) receptor have selective effects on constitutive, TSH-, and TSH receptor autoantibody-stimulated phosphoinositide and 3',5'-cyclic adenosine monophosphate signal generation.  |  Kosugi, S., et al. 1993. Mol Endocrinol. 7: 1009-20. PMID: 7901757
2. Multimeric complex formation by the thyrotropin receptor in solubilized thyroid membranes.  |  Graves, PN., et al. 1996. Endocrinology. 137: 3915-20. PMID: 8756566
3. Immunoradiometric and luminescence immunoenzymometric assay of human thyrotropin from dried blood spots for screening of neonatal hypothyroidism.  |  Jirkalová, V., et al. 1996. Eur J Clin Chem Clin Biochem. 34: 823-7. PMID: 8933106
4. The rat TSHbeta gene contains distinct response elements for regulation by retinoids and thyroid hormone.  |  Breen, JJ., et al. 1997. Mol Cell Endocrinol. 131: 137-46. PMID: 9296372
5. Understanding the thyrotropin receptor function-structure relationship.  |  Sanders, J., et al. 1997. Baillieres Clin Endocrinol Metab. 11: 451-79. PMID: 9532334
6. Functional homodimeric glycoprotein hormones: implications for hormone action and evolution.  |  Moyle, WR., et al. 1998. Chem Biol. 5: 241-54. PMID: 9646940