TNF-R2 Antibody (D-2): sc-8041

TNF-R2 Antibody (D-2) is a mouse monoclonal IgG2a antibody that detects TNF-R2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). TNF-R2 Antibody (D-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TNF-R2 protein, also known as TNFRSF1B, plays a crucial role in mediating the effects of tumor necrosis factor (TNF), a key cytokine involved in systemic inflammation and immune responses. Unlike TNF-R1, which is widely expressed and mediates most TNF functions, TNF-R2 is primarily expressed on immune cells and is involved in promoting cell survival, proliferation, and differentiation. This selective expression is significant as TNF-R2′s role in modulating immune responses, particularly in the context of autoimmune diseases and cancer, where TNF-R2 signaling pathways can influence the balance between pro-inflammatory and anti-inflammatory responses. Understanding the interactions and signaling mechanisms of TNF-R2 is essential for developing targeted therapies that can manipulate these pathways for therapeutic benefit.

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TNF-R2 Antibody (D-2) References:

1. TNF-R2 expression in acquired middle ear cholesteatoma.  |  Vitale, RF., et al. 2011. Braz J Otorhinolaryngol. 77: 531-536. PMID: 21860983
2. Comparative Analysis of TNF-alpha, TNF-R1, and TNF-R2 in Patients with Low-impact Fractures Due to Osteoporosis.  |  Teixeira, AOM., et al. 2023. Rev Bras Ortop (Sao Paulo). 58: 495-499. PMID: 37396087
3. Maintenance of Lognormal-Like Skewed Dendritic Spine Size Distributions in Dentate Granule Cells of TNF, TNF-R1, TNF-R2, and TNF-R1/2-Deficient Mice.  |  Rößler, N., et al. 2024. J Comp Neurol. 532: e25645. PMID: 38943486
4. Self-association of the 'death domains' of the p55 tumor necrosis factor (TNF) receptor and Fas/APO1 prompts signaling for TNF and Fas/APO1 effects.  |  Boldin, MP., et al. 1995. J Biol Chem. 270: 387-91. PMID: 7529234
5. The Fas death factor.  |  Nagata, S. and Golstein, P. 1995. Science. 267: 1449-56. PMID: 7533326
6. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis.  |  Chinnaiyan, AM., et al. 1995. Cell. 81: 505-12. PMID: 7538907
7. RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death.  |  Stanger, BZ., et al. 1995. Cell. 81: 513-23. PMID: 7538908
8. The death domain motif found in Fas (Apo-1) and TNF receptor is present in proteins involved in apoptosis and axonal guidance.  |  Hofmann, K. and Tschopp, J. 1995. FEBS Lett. 371: 321-3. PMID: 7556620
9. Contenders in FasL/TNF death signaling.  |  Cleveland, JL. and Ihle, JN. 1995. Cell. 81: 479-82. PMID: 7758103
10. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation.  |  Hsu, H., et al. 1995. Cell. 81: 495-504. PMID: 7758105
11. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death.  |  Smith, CA., et al. 1994. Cell. 76: 959-62. PMID: 8137429
12. Transducers of life and death: TNF receptor superfamily and associated proteins.  |  Baker, SJ. and Reddy, EP. 1996. Oncogene. 12: 1-9. PMID: 8552378

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TNF-R2 Antibody (D-2) has 27 citations in a variety of scientific publications.

Primary antibodies like Anti-TNF-R2 Antibody (D-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TNF-R2 Antibody (D-2) Specifications

Alternate Product Name: TNFR2

Product Clone Name: D-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids: 260-461

Epitope Target: TNF-R2

Epitope Species: human

Product Reactivity/Detection: TNF-R2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 27 citations in various scientific publications

Available Conjugates/Forms for TNF-R2 Antibody (D-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin