TIP120A Antibody (D-9): sc-373718
- TIP120A Antibody (D-9) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-21 at the N-terminus of TIP120A of rat origin
- recommended for detection of TIP120A of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, bovine and porcine
- TransCruz reagent for ChIP application (sc-373718 X, 200 µg/0.1 ml)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TIP120A Antibody (D-9). This work is in progress.
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TIP120A Antibody (D-9) is a mouse monoclonal IgM antibody that detects TIP120A in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TIP120A is a crucial protein that plays a significant role in transcriptional regulation by forming complexes with the TATA-binding protein (TBP) and various nuclear proteins. This interaction facilitates the integration of RNA polymerase II into the preinitiation complex, a key step in the initiation of gene transcription. TIP120A (D-9) antibody enables researchers to study how TIP120A binds directly to TBP and specific subunits of RNA polymerases, underscoring its importance in regulating gene expression across multiple pathways. Additionally, TIP120A exhibits chaperone-like activity, which enhances the stability of RNA polymerases and amplifies the expression of numerous genes, making TIP120A an essential player in cellular processes. Anti-TIP120A antibody (D-9) serves as an invaluable tool for researchers studying transcriptional regulation and gene expression dynamics in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TIP120A Antibody (D-9) References:
- NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases. | Liu, J., et al. 2002. Mol Cell. 10: 1511-8. PMID: 12504025
- Recruitment of the inhibitor Cand1 to the cullin substrate adaptor site mediates interaction to the neddylation site. | Helmstaedt, K., et al. 2011. Mol Biol Cell. 22: 153-64. PMID: 21119001
- COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. | Mao, X., et al. 2011. J Biol Chem. 286: 32355-65. PMID: 21778237
- CAND1 promotes PLK4-mediated centriole overduplication and is frequently disrupted in prostate cancer. | Korzeniewski, N., et al. 2012. Neoplasia. 14: 799-806. PMID: 23019411
- Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins. | Pierce, NW., et al. 2013. Cell. 153: 206-15. PMID: 23453757
- CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire. | Wu, S., et al. 2013. Nat Commun. 4: 1642. PMID: 23535663
- CAND1 exchange factor promotes Keap1 integration into cullin 3-RING ubiquitin ligase during adipogenesis. | Dubiel, D., et al. 2015. Int J Biochem Cell Biol. 66: 95-100. PMID: 26219975
- miR-33a inhibits cell proliferation and invasion by targeting CAND1 in lung cancer. | Kang, M., et al. 2018. Clin Transl Oncol. 20: 457-466. PMID: 28871425
- LncRNA RMRP knockdown promotes proliferation and migration of Schwann cells by mediating the miR-766-5p/CAND1 axis. | Zhou, L., et al. 2022. Neurosci Lett. 770: 136440. PMID: 34974108
- GSTM3 deficiency impedes DNA mismatch repair to promote gastric tumorigenesis via CAND1/NRF2-KEAP1 signaling. | Chen, T., et al. 2022. Cancer Lett. 538: 215692. PMID: 35487311
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TIP120A Antibody (D-9) | sc-373718 | 200 µg/ml | $322.00 | |||
TIP120A (D-9) Neutralizing Peptide | sc-373718 P | 100 µg/0.5 ml | $69.00 | |||
TIP120A Antibody (D-9) X | sc-373718 X | 200 µg/0.1 ml | $322.00 |