Taxol Antibody (69E4A8E): sc-69899

Taxol Antibody (69E4A8E) is a mouse monoclonal IgG1 kappa light chain antibody that detects Taxol protein in non-species reactive applications by enzyme-linked immunosorbent assay (ELISA). anti-Taxol antibody (69E4A8E) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. Taxol, also known as Paclitaxel, is a potent mitotic inhibitor derived from the bark of the Pacific yew tree (Taxus brevifolia) and plays a crucial role in cancer therapy, particularly for ovarian, lung, breast, prostate, head and neck cancers, among others. Taxol′s primary function is to disrupt normal microtubule dynamics during cell division, which is essential for halting the proliferation of cancer cells. Specifically, Taxol binds to β-tubulin, promoting microtubule polymerization and stabilization, leading to G2/M phase arrest and triggering apoptosis in malignant cells. However, Taxol′s therapeutic efficacy is often compromised by the development of drug resistance and significant side effects, including peripheral neurotoxicity, which affects large myelinated nerve fibers and can result in debilitating motor and sensory dysfunction. Taxol monoclonal antibody (69E4A8E) allows researchers to further investigate the mechanisms of action and resistance associated with this important chemotherapeutic agent, facilitating advancements in cancer treatment strategies.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Taxol Antibody (69E4A8E) References:

1. Chemotherapy-induced peripheral neuropathy.  |  Hilkens, PH. and ven den Bent, MJ. 1997. J Peripher Nerv Syst. 2: 350-61. PMID: 10975744
2. The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density.  |  Snyder, JP., et al. 2001. Proc Natl Acad Sci U S A. 98: 5312-6. PMID: 11309480
3. Taxol: a review of its preclinical in vivo antitumor activity.  |  Rose, WC. 1992. Anticancer Drugs. 3: 311-21. PMID: 1358264
4. Expression of beta-tubulin isotypes in human primary ovarian carcinoma.  |  Ohishi, Y., et al. 2007. Gynecol Oncol. 105: 586-92. PMID: 17343904
5. Up-regulation of alphavbeta3 integrin expression is a novel molecular response to chemotherapy-induced cell damage in a heregulin-dependent manner.  |  Vellon, L., et al. 2007. Differentiation. 75: 819-30. PMID: 17999741
6. High-throughput screening of microtubule-interacting drugs.  |  Bane, SL., et al. 2007. Methods Mol Med. 137: 281-8. PMID: 18085236
7. Understanding tubulin/microtubule-taxane interactions: a quantitative structure-activity relationship study.  |  Hansch, C. and Verma, RP. 2008. Mol Pharm. 5: 151-61. PMID: 18171015
8. Microtubule-stabilizing natural products as promising cancer therapeutics.  |  Gallagher, BM. 2007. Curr Med Chem. 14: 2959-67. PMID: 18220732
9. Interleukin-6 protects against paclitaxel, cisplatin and vincristine-induced neuropathies without impairing chemotherapeutic activity.  |  Callizot, N., et al. 2008. Cancer Chemother Pharmacol. 62: 995-1007. PMID: 18270703
10. Development of Taxol and other endophyte produced anti-cancer agents.  |  Miller, K., et al. 2008. Recent Pat Anticancer Drug Discov. 3: 14-9. PMID: 18289120
11. [Taxol--a new cytostatic drug for therapy of ovarian and breast cancer].  |  Meden, H., et al. 1994. Geburtshilfe Frauenheilkd. 54: 187-93. PMID: 7912212
12. Taxol neuropathy. Electrodiagnostic and sural nerve biopsy findings.  |  Sahenk, Z., et al. 1994. Arch Neurol. 51: 726-9. PMID: 7912506

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Taxol Antibody (69E4A8E) has 3 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Taxol Antibody (69E4A8E) Specifications

Alternate Product Name: Taxol

Product Clone Name: 69E4A8E

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Taxol

Epitope Species: N/A

Product Reactivity/Detection: Taxol

Species Reactivity/Detection: NSR

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for Taxol Antibody (69E4A8E): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin