아미노 산 1534-1737 mapping within an internal region of TANC2 of human 의하고 기원한다
안티-TANC2 항체 (D-11)는 WB, IP, IF and ELISA으로 mouse, rat and human유래의 TANC2 를 감지하는 데에 추천한다.
IP를 위해 agarose ;WB, IHC(P) and ELISA를 위해 HRP ;또는 IF, IHC(P) and FCM를 위해 phycoerythrin or FITC 에 결합된 Anti-TANC2 항체 (D-11)를 제공한다.
WB (RGB), IF, IHC(P) 와FCM, RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647결합제품도 있습니다.
WB (NIR), IF와FCM,Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 680 or Alexa Fluor® 790 결합제품도 있습니다.
m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred detection reagent for TANC2 Antibody (D-11) for WB applications. This reagent is now offered in a bundle with TANC2 Antibody (D-11) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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TANC2 Antibody (D-11) is a high quality monoclonal TANC2 antibody (also designated TANC2 antibody) suitable for the detection of the TANC2 protein of mouse, rat and human origin. TANC2 Antibody (D-11) is available as both the non-conjugated anti-TANC2 antibody form, as well as multiple conjugated forms of anti-TANC2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. TANC2 (tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2), also known as rolling pebbles homolog B, is a 1,990 amino acid protein that belongs to the TANC family and exists as four alternatively spliced isoforms. TANC2 contains eleven ANK repeats and three TPR repeats. The gene that encodes TANC2 contains 418,170 bases and maps to human chromosome 17q23.3. Encoding over 1,200 genes, chromosome 17 comprises over 2.5% of the human genome. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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