Syk Inhibitor II CAS: 227449-73-2
MF: C14H15F3N6O•2HCl•2H2O
A cell-permeable pyrimidine-carboxamide compound that acts as a potent, selective, and ATP-competitive inhibitor of Syk (IC50 = 41 nM).

Syk Inhibitor II (CAS 227449-73-2)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 111ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Application Syk Inhibitor II is a cell-permeable pyrimidine-carboxamide compound that acts as a potent, selective, and ATP-competitive inhibitor of Syk (IC50 = 41 nM
CAS 등록번호: 227449-73-2
분자량: 449.26
분자식: C14H15F3N6O•2HCl•2H2O
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).
이 제품의 리뷰를 쓰고 15 CruzCredits를 받기

Syk Inhibitor II, a cell-permeable pyrimidine-carboxamide compound that acts as a potent, selective, and ATP-competitive inhibitor of Syk (IC50 = 41 nM), while affecting PKCe, PKCbII, ZAP-70, Btk, and Itk only at much higher concentrations (IC50 = 5.1, 11, 11.2, 15.5, and 22.6μM, respectively). Inhibits FceRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC50 = 460 nM) and passive cutaneous anaphylaxis (PCA) reaction in mice in vivo (ID50 = 13.2 mg/kg, s.c.).


References

Hisamichi, H., et al. 2005. Bioorg. Med. Chem. 13, 4936.

Physical State :
Solid
용해도 :
Soluble in water (25 mg/ml), and DMSO (100 mg/ml).
저장 :
Store at 4° C
굴절률 :
n20D ~1.63 (Predicted)
IC50 :
Syk: IC50 = 41 nM; PKCε: IC50 = 5.1 µM; PKCβII: IC50 = 11 µM; ZAP-70: IC50 = 11.2 µM; Btk: IC50 = 15.5 µM; Itk: IC50 = 22.6 µM; FcεRI-mediated 5-HT release: IC50 = 460 nM (RBL-2H3 cells); Lysyl-tRNA synthetase: IC50 = 41 nM (human)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
PubChem CID :
16760670
SMILES :
C1=CC(=CC(=C1)NC2=NC(=NC=C2C(=O)N)NCCN)C(F)(F)F.O.O.Cl.Cl

SDS(MSDS)다운로드

분석증명서

PDF문서를 열람,
프린트와 코멘트를 작성하려면 Adobe Acrobat Reader가 필요합니다.

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 144ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 9ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

산타크루즈바이오테크놀러지는 생물의학연구에 필요한 제품을 개발하는 선구자입니다. Toll Free 1-800-457-3801로 연락주세요. Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. 판권소유. "Santa Cruz Biotechnology", 와 Santa Cruz Biotechnology, Inc. 로고, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", 및 San Juan Ranch 로고, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz"와 "EZ Touch" 는 Santa Cruz Biotechnology, Inc의 등록된 상표입니다. 모든 상표는 각자 소유주의 소유입니다.