Succinylacetone CAS: 51568-18-4
MF: C7H10O4
MW: 158.15

Succinylacetone (CAS 51568-18-4)

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Alternate Names: Succinylacetone is also known as 4,6-Dioxoheptanoic Acid.
Application Succinylacetone is a catabolic byproduct of tyrosine breakdown and an inhbitor of heme biosynthesis.
CAS 등록번호: 51568-18-4
분자량: 158.15
분자식: C7H10O4
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Succinylacetone (SA) is a specific marker for the inherited metabolic disease, hepatorenal tyrosinemia. Succinylacetone was developed to create a stable-isotope for the determination of SA in dried blood spots (DBS) and liquid urine, wherein using a 13C4-SA as an internal standard. For the quantification of Succinylacetone from Plasmodium falciparum cultures, Succinylacetone is used as a standard. Succinylacetone is a component of dendritic cell conditioning medium. In the inhibition of ALA dehydratase (ALAD) in dendritic cells, Succinylacetone is also a component.


References

1. Lindstedt, S., et al., 1992. Treatment of hereditary tyrosinaemia type I by inhibition of 4-hydroxyphenylpyruvate dioxygenase. Lancet. 340(8823): 813-7. PMID: 1383656

2. Kvittingen, E A., et al., 1991. Tyrosinaemia type I--an update. Journal of inherited metabolic disease. 14(4): 554-62. PMID: 1749221

3. Schulze, A., et al., 2001. Spectrophotometric microassay for delta-aminolevulinate dehydratase in dried-blood spots as confirmation for hereditary tyrosinemia type I. Clinical chemistry. 47(8): 1424-9. PMID: 11468232

4. Allard, Pierre., et al., 2004. Newborn screening for hepatorenal tyrosinemia by tandem mass spectrometry: analysis of succinylacetone extracted from dried blood spots. Clinical biochemistry. 37(11): 1010-5. PMID: 15498530

Appearance :
Powder
Physical State :
Solid
저장 :
Store at -20° C
녹는점 :
66-67° C
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
PubChem CID :
SMILES :
CC(=O)CC(=O)CCC(=O)O

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