SSTR1 Antibody (1F7): sc-293490
- SSTR1 Antibody (1F7) is a mouse monoclonal IgG2b κ SSTR1 antibody, cited in 1 publications, provided at 100 µg/ml
- raised against amino acids 1-60 representing partial length SSTR1 of human origin
- recommended for detection of SSTR1 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SSTR1 Antibody (1F7). This work is in progress.
QUICK LINKS
SSTR1 Antibody (1F7) is a mouse monoclonal IgG2b kappa light chain antibody that detects the SSTR1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-SSTR1 antibody (1F7) is available as the non-conjugated format. SSTR1 protein is a member of the somatostatin receptor family, which consists of five distinct subtypes that play crucial roles in mediating the biological effects of somatostatin, a peptide hormone involved in the regulation of various physiological processes, including inhibition of hormone secretion and modulation of neurotransmission. SSTR1 is primarily located on the cell membrane, where SSTR1 functions as a G-protein-coupled receptor, facilitating intracellular signaling pathways that can inhibit adenylyl cyclase activity and regulate calcium ion channels. This localization is vital for SSTR1′s role in controlling cellular responses to somatostatin, impacting processes such as cell proliferation and differentiation. Additionally, SSTR1 can form functional homo- and heterodimers with other somatostatin receptor subtypes, enhancing the complexity and specificity of somatostatin signaling. SSTR1′s ability to interact with multiple signaling pathways underscores SSTR1′s importance in various physiological and pathological contexts, making SSTR1 (1F7) monoclonal antibody a valuable tool for researchers studying somatostatin-related functions and disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SSTR1 Antibody (1F7) References:
- Somatostatin and its receptor family. | Patel, YC. 1999. Front Neuroendocrinol. 20: 157-98. PMID: 10433861
- Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers. | Rocheville, M., et al. 2000. J Biol Chem. 275: 7862-9. PMID: 10713101
- Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity. | Rocheville, M., et al. 2000. Science. 288: 154-7. PMID: 10753124
- Expression of multiple somatostatin receptor genes in AtT-20 cells. Evidence for a novel somatostatin-28 selective receptor subtype. | Patel, YC., et al. 1994. J Biol Chem. 269: 1506-9. PMID: 7904601
- Activation in vitro of somatostatin receptor subtypes 2, 3, or 4 stimulates protein tyrosine phosphatase activity in membranes from transfected Ras-transformed NIH 3T3 cells: coexpression with catalytically inactive SHP-2 blocks responsiveness. | Reardon, DB., et al. 1997. Mol Endocrinol. 11: 1062-9. PMID: 9212054
- C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest. | Sharma, K., et al. 1999. Mol Endocrinol. 13: 82-90. PMID: 9892014
- Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis. | Kumar, U., et al. 1999. Diabetes. 48: 77-85. PMID: 9892225
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SSTR1 Antibody (1F7) | sc-293490 | 100 µg/ml | $322.00 |