SREB3 Antibody (C-8): sc-518232

SREB3 Antibody (C-8) is a mouse monoclonal IgM antibody specific for an epitope mapping between amino acids 166-186 of SREB3 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SREB3 monoclonal antibody (C-8) is available as the non-conjugated form. Super conserved receptor expressed in brain 3 (SREB3), also known as G protein-coupled receptor (GPR173), is an orphan G protein-coupled receptor primarily expressed in brain and ovarian tissues. The significance of SREB3 lies in its role in mediating various physiological processes, although specific ligands remain unidentified. SREB3 is thought to be involved in critical signaling pathways that influence neuronal function and reproductive health, making SREB3 a vital target for research into neurological disorders and reproductive biology. Understanding the interactions and signaling mechanisms of SREB3 can provide insights into potential roles in health and disease, highlighting the importance of anti-SREB3 antibody (C-8) in advancing knowledge of G protein-coupled receptor biology. By targeting SREB3 in human samples, SREB3 (C-8) antibody offers researchers a valuable tool for investigating expression, localization, and function of SREB3, facilitating deeper insights into roles in neurological and reproductive systems.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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SREB3 Antibody (C-8) References:

1. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system.  |  Matsumoto, M., et al. 2000. Biochem Biophys Res Commun. 272: 576-82. PMID: 10833454
2. The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31.  |  Hellebrand, S., et al. 2000. Biochim Biophys Acta. 1493: 269-72. PMID: 10978537
3. Gpr85, a novel member of the G-protein coupled receptor family, prominently expressed in the developing mouse cerebral cortex.  |  Hellebrand, S., et al. 2001. Brain Res Gene Expr Patterns. 1: 13-6. PMID: 15018813
4. A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain.  |  Matsumoto, M., et al. 2005. Brain Res Mol Brain Res. 138: 58-69. PMID: 15893849
5. Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain.  |  Yanai, T., et al. 2016. Genes Cells. 21: 717-27. PMID: 27184081
6. Hypothalamic action of phoenixin to control reproductive hormone secretion in females: importance of the orphan G protein-coupled receptor Gpr173.  |  Stein, LM., et al. 2016. Am J Physiol Regul Integr Comp Physiol. 311: R489-96. PMID: 27440717
7. Regulation of Gpr173 expression, a putative phoenixin receptor, by saturated fatty acid palmitate and endocrine-disrupting chemical bisphenol A through a p38-mediated mechanism in immortalized hypothalamic neurons.  |  McIlwraith, EK., et al. 2019. Mol Cell Endocrinol. 485: 54-60. PMID: 30716364
8. Effect of the neuropeptide phoenixin and its receptor GPR173 during folliculogenesis.  |  Nguyen, XP., et al. 2019. Reproduction. 158: 25-34. PMID: 30933929
9. GPR173 agonist phoenixin 20 promotes osteoblastic differentiation of MC3T3-E1 cells.  |  Gu, Z., et al. 2020. Aging (Albany NY). 13: 4976-4985. PMID: 33196456
10. Super-conserved receptors expressed in the brain: biology and medicinal chemistry efforts.  |  Bayrak, A., et al. 2022. Future Med Chem. 14: 899-913. PMID: 35535715
11. A Novel CCK Receptor GPR173 Mediates Potentiation of GABAergic Inhibition.  |  He, L., et al. 2023. J Neurosci. 43: 2305-2325. PMID: 36813575
12. Discovery of three novel G-protein-coupled receptor genes.  |  O'Dowd, BF., et al. 1998. Genomics. 47: 310-3. PMID: 9479505

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SREB3 Antibody (C-8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SREB3 Antibody (C-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SREB3 Antibody (C-8) Specifications

Alternate Product Name: SREB3

Product Clone Name: C-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 166-186

Epitope Target: SREB3

Epitope Species: human

Product Reactivity/Detection: SREB3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SREB3 Antibody (C-8): N/A