Spermidine/putrescine extracellular binding protein Antibody (E-1): sc-398930

Spermidine/putrescine extracellular binding protein Antibody (E-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects Spermidine/putrescine extracellular binding protein of Streptococcus equi origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Spermidine/putrescine extracellular binding protein antibody (E-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Spermidine/putrescine extracellular binding protein plays a crucial role in the transport and metabolism of polyamines, which are essential for cellular growth and function. These polyamines, including spermidine and putrescine, are involved in various cellular processes such as DNA stabilization, gene expression regulation, and cell proliferation. Streptococcus equi′s ability to bind these polyamines enhances bacterial virulence by promoting growth in the host environment, thereby facilitating infection. Streptococcus equi subspecies equi, the equine host-adapted pathogen responsible for strangles, can lead to severe health issues in horses, including fever, depression, and respiratory distress due to lymphadenitis. Understanding Spermidine/putrescine extracellular binding protein function is vital for developing therapeutic strategies against infections caused by this pathogen.

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Spermidine/putrescine extracellular binding protein Antibody (E-1) References:

1. Getting to grips with strangles: an effective multi-component recombinant vaccine for the protection of horses from Streptococcus equi infection.  |  Guss, B., et al. 2009. PLoS Pathog. 5: e1000584. PMID: 19763180
2. Molecular characterisation of 'strangles' outbreaks in the UK: the use of M-protein typing of Streptococcus equi ssp. equi.  |  Ivens, PA., et al. 2011. Equine Vet J. 43: 359-64. PMID: 21492215
3. Association of Streptococcus equi with equine monocytes.  |  Mérant, C., et al. 2011. Vet Immunol Immunopathol. 143: 83-6. PMID: 21752476
4. Streptococcus equi: a pathogen restricted to one host.  |  Waller, AS., et al. 2011. J Med Microbiol. 60: 1231-1240. PMID: 21757503
5. Streptococcus equi subspecies equi infection (strangles) in horses.  |  Boyle, A. 2011. Compend Contin Educ Vet. 33: E1-7; quiz E8. PMID: 21870348
6. Antiphagocytic function of an IgG glycosyl hydrolase from Streptococcus equi subsp. equi and its use as a vaccine component.  |  Flock, M., et al. 2012. Infect Immun. 80: 2914-9. PMID: 22615244
7. Development of a novel mucosal vaccine against strangles by supercritical enhanced atomization spray-drying of Streptococcus equi extracts and evaluation in a mouse model.  |  Rodrigues, MA., et al. 2012. Eur J Pharm Biopharm. 82: 392-400. PMID: 22841882
8. Detection of Streptococcus equi subspecies equi using a triplex qPCR assay.  |  Webb, K., et al. 2013. Vet J. 195: 300-4. PMID: 22884566

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Spermidine/putrescine extracellular binding protein Antibody (E-1) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Spermidine/putrescine extracellular binding protein Antibody (E-1) Specifications

Alternate Product Name: Spermidine/putrescine extracellular binding protein

Product Clone Name: E-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-357

Epitope Target: Spermidine/putrescine extracellular binding protein

Epitope Species: Streptococcus equi subsp. equi 4047

Product Reactivity/Detection: Spermidine/putrescine extracellular binding protein

Species Reactivity/Detection: Streptococcus equi

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Spermidine/putrescine extracellular binding protein Antibody (E-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin