SMG1 Antibody (6-RE13): sc-135563
- SMG1 Antibody (6-RE13) is a mouse monoclonal IgG2a κ, cited in 5 publications, provided at 100 µg/ml
- raised against recombinant SMG1 protein of human origin
- recommended for detection of SMG1 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SMG1 Antibody (6-RE13). This work is in progress.
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SMG1 Antibody (6-RE13) is a mouse monoclonal IgG2a antibody that detects SMG1 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). SMG1, also known as ATX or LIP, is a crucial serine/threonine protein kinase composed of 3,657 amino acids, which is localized in both the nucleus and cytoplasm. SMG1 features a unique structural composition that includes one FAT domain, one FATC domain, one HEAT repeat, and one phosphoinositide 3-kinase (PI3K) domain, all of which contribute to functional versatility. These domains facilitate SMG1′s role in mRNA surveillance and cellular response to genotoxic stress, processes that are vital for maintaining cellular integrity and function. SMG1 utilizes manganese as a cofactor to catalyze the phosphorylation of target proteins, thereby regulating essential cellular functions such as cell division and apoptosis. Multiple isoforms of SMG1, resulting from alternative splicing, underscore the complexity of regulatory mechanisms and potential interactions within various signaling pathways.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SMG1 Antibody (6-RE13) | sc-135563 | 100 µg/ml | $339.00 |