SAF-B2 Antibody (A-9): sc-393455
- SAF-B2 Antibody (A-9) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 101-207 mapping within an internal region of SAF-B2 of mouse origin
- recommended for detection of SAF-B2 of mouse origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SAF-B2 Antibody (A-9) for WB applications. These reagents are now offered in bundles with SAF-B2 Antibody (A-9) (see ordering information below).
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SAF-B2 Antibody (A-9) is a mouse monoclonal IgG1 antibody that detects SAF-B2 in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SAF-B2, or scaffold attachment factor B2, is a crucial nuclear matrix-associated protein that plays a significant role in the regulation of gene expression by binding to matrix- or scaffold-associating regions (MARs or SARs) on DNA. This interaction is vital for the proper functioning of RNA polymerase II, which is responsible for synthesizing messenger RNA from DNA templates. Additionally, SAF-B2 interacts with serine-/arginine-rich RNA processing factors, which are essential for pre-mRNA splicing and transport. The presence of SAF-B2 in both the nucleus and cytoplasm highlights its multifaceted role in cellular processes, including its potential involvement in breast cancer, where SAF-B2 may influence cellular proliferation and division. Using anti-SAF-B2 antibody (A-9), researchers can gain insights into the dynamics of RNA processing and the implications of SAF-B2 in various biological contexts, particularly in cancer research.
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SAF-B2 Antibody (A-9) References:
- SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor. | Townson, SM., et al. 2003. J Biol Chem. 278: 20059-68. PMID: 12660241
- Scaffold attachment factors SAFB1 and SAFB2: Innocent bystanders or critical players in breast tumorigenesis? | Oesterreich, S. 2003. J Cell Biochem. 90: 653-61. PMID: 14587024
- Alternative RNA splicing complexes containing the scaffold attachment factor SAFB2. | Sergeant, KA., et al. 2007. J Cell Sci. 120: 309-19. PMID: 17200140
- Scaffold attachment factor B (SAFB)1 and SAFB2 cooperatively inhibit the intranuclear mobility and function of ERα. | Hashimoto, T., et al. 2012. J Cell Biochem. 113: 3039-50. PMID: 22566185
- SAFB1- and SAFB2-mediated transcriptional repression: relevance to cancer. | Hong, EA., et al. 2012. Biochem Soc Trans. 40: 826-30. PMID: 22817742
- Scaffold attachment factor B2 (SAFB2)-null mice reveal non-redundant functions of SAFB2 compared with its paralog, SAFB1. | Jiang, S., et al. 2015. Dis Model Mech. 8: 1121-7. PMID: 26092125
- The increasing diversity of functions attributed to the SAFB family of RNA-/DNA-binding proteins. | Norman, M., et al. 2016. Biochem J. 473: 4271-4288. PMID: 27888239
- SAFB2 Enables the Processing of Suboptimal Stem-Loop Structures in Clustered Primary miRNA Transcripts. | Hutter, K., et al. 2020. Mol Cell. 78: 876-889.e6. PMID: 32502422
- SAFB2 Inhibits the Progression of Breast Cancer by Suppressing the Wnt/β-Catenin Signaling Pathway via NFAT5. | Zhen, H., et al. 2023. Mol Biotechnol. 65: 1465-1475. PMID: 36652182
- Blood transcriptome sequencing identifies biomarkers able to track disease stages in spinocerebellar ataxia type 3. | Raposo, M., et al. 2023. Brain. 146: 4132-4143. PMID: 37071051
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SAF-B2 Antibody (A-9) | sc-393455 | 200 µg/ml | $322.00 | |||
SAF-B2 Antibody (A-9): m-IgG Fc BP-HRP Bundle | sc-538223 | 200 µg Ab; 10 µg BP | $361.00 | |||
SAF-B2 Antibody (A-9): m-IgGκ BP-HRP Bundle | sc-535791 | 200 µg Ab; 40 µg BP | $361.00 | |||
SAF-B2 Antibody (A-9): m-IgG1 BP-HRP Bundle | sc-545587 | 200 µg Ab; 20 µg BP | $361.00 |