RJR 2403 oxalate (CAS 183288-99-5)
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Available in US only.
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RJR 2403 oxalate stands out as a distinguished compound in neuroscientific research due to its unique interaction with the central nervous system′s (CNS) acetylcholine receptors (AChRs), particularly demonstrating a remarkable affinity for the alpha4beta2 nicotinic acetylcholine receptor subtype. Its mechanism of action is intricately linked to its ability to selectively bind to these receptors with a Ki (equilibrium dissociation constant) value of 26 nM, highlighting its potent agonistic properties towards the alpha4beta2 subtype, compared to a significantly weaker affinity for the alpha7 subtype, with a Ki value of 36,000 nM. This stark contrast in selectivity underscores the compound′s utility in neurobiological research, providing a powerful tool for elucidating the functional roles of nicotinic acetylcholine receptors in the CNS. By acting as an agonist, RJR 2403 oxalate facilitates the study of cholinergic signaling pathways, offering insights into their contribution to cognitive processes and the complex interplay of neurotransmitter systems within the brain.
RJR 2403 oxalate (CAS 183288-99-5) References
- Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist. | Damaj, MI., et al. 1999. J Pharmacol Exp Ther. 291: 390-8. PMID: 10490929
- Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses. | Li, YF., et al. 2009. Neurosci Lett. 462: 20-3. PMID: 19573576
- α4β2 nicotinic acetylcholine receptors in the early postnatal mouse superior cervical ganglion. | Scholze, P., et al. 2011. Dev Neurobiol. 71: 390-9. PMID: 21485013
- α7 Nicotinic acetylcholine receptor agonist attenuates neuropathological changes associated with intracerebral hemorrhage in mice. | Hijioka, M., et al. 2012. Neuroscience. 222: 10-9. PMID: 22820264
- Nicotine increases GABAergic input on rat dorsal raphe serotonergic neurons through alpha7 nicotinic acetylcholine receptor. | Hernández-Vázquez, F., et al. 2014. J Neurophysiol. 112: 3154-63. PMID: 25231613
- Nicotinic α7 receptor activation selectively potentiates the function of NMDA receptors in glutamatergic terminals of the nucleus accumbens. | Zappettini, S., et al. 2014. Front Cell Neurosci. 8: 332. PMID: 25360085
- Nicotinic α7 and α4β2 agonists enhance the formation and retrieval of recognition memory: Potential mechanisms for cognitive performance enhancement in neurological and psychiatric disorders. | McLean, SL., et al. 2016. Behav Brain Res. 302: 73-80. PMID: 26327238
- Nicotinic Acetylcholine Receptors Control Encoding and Retrieval of Associative Recognition Memory through Plasticity in the Medial Prefrontal Cortex. | Sabec, MH., et al. 2018. Cell Rep. 22: 3409-3415. PMID: 29590611
- Co-activation of selective nicotinic acetylcholine receptors is required to reverse beta amyloid-induced Ca2+ hyperexcitation. | Sun, JL., et al. 2019. Neurobiol Aging. 84: 166-177. PMID: 31629115
- Nicotine Increases Spontaneous Glutamate Release in the Rostromedial Tegmental Nucleus. | Castillo-Rolón, D., et al. 2020. Front Neurosci. 14: 604583. PMID: 33519359
- Selective coactivation of α7- and α4β2-nicotinic acetylcholine receptors reverses beta-amyloid-induced synaptic dysfunction. | Roberts, JP., et al. 2021. J Biol Chem. 296: 100402. PMID: 33571523
- Nicotinic aspects of the discriminative stimulus effects of arecoline. | Winger, G. 2021. Behav Pharmacol. 32: 581-589. PMID: 34417356
- Nicotinic Acetylcholine Receptors and Microglia as Therapeutic and Imaging Targets in Alzheimer's Disease. | Takata, K., et al. 2022. Molecules. 27: PMID: 35566132
- RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization. | Bencherif, M., et al. 1996. J Pharmacol Exp Ther. 279: 1413-21. PMID: 8968366
- RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization. | Lippiello, PM., et al. 1996. J Pharmacol Exp Ther. 279: 1422-9. PMID: 8968367
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RJR 2403 oxalate, 10 mg | sc-204884 | 10 mg | $189.00 | |||
| US: Only available in the US | ||||||
RJR 2403 oxalate, 50 mg | sc-204884A | 50 mg | $785.00 | |||
| US: Only available in the US | ||||||