rac 5-Hydroxy Valproic Acid-d7 Sodium Salt

rac 5-Hydroxy Valproic Acid-d7 Sodium Salt is a deuterium-labelled metabolite of Valproic Acid. The unlabelled version of this compound, rac 5-Hydroxy Valproic Acid (sc-208266) has been reported to be the product of the metabolism of Valproic Acid via CYP4B1, as demonstrated using monospecific polyclonal antibodies directed against CYP4B1. Valproic Acid, the parent compound of the labelled metabolite, is a branched chain, fatty acid which is reported to potentially enhance central GABAergic neurotransmission and inhibit Na⁺ channels. Currently, the various molecular mechanisms of action of Valproic Acid have not been completely elucidated. Valproic Acid has been reported to be a potent inhibitor of histone deacetylases (HDACs) in vitro. Valproic Acid is also noted to relieve HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. In animal studies, Valproic Acid has been observed to reduce tumor growth and metastasis formation. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A (sc-3511) in the inhibition of histone deacetylase.

Metabolites of Valproic Acid are also available as:
Valproic Acid (sc-213144)
Valproic Acid, Sodium Salt (sc-202378)
3-Hydroxy Valproic Acid (sc-209599)
3-Keto Valproic Acid Sodium Salt (sc-216476)
4-Hydroxy Valproic Acid Sodium Salt(Mixture of Diastereomers) (sc-216870)
rac 5-Hydroxy Valproic Acid Sodium Salt (sc-208266)
Valproic Acid β-D-Glucuronide Allyl Ester (sc-220360)
Valproic Acid &beat;-D-Glucuronide (sc-213145)

Labelled forms of Valproic Acid are available as:
Valproic Acid-d6 (sc-213146)
Valproic Acid-d6 β-D-Glucuronide (sc-220361)